Anti- and prooxidant effects of chronic quercetin administration in rats
Anti- and prooxidant effects of chronic quercetin administration in rats
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DOI：
10.1016/j.ejphar.2003.09.067
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发表时间：
2003-12-15
影响因子：
5
通讯作者：
Lee, BH
中科院分区：
文献类型：
--
作者：
Choi, EJ;Chee, KM;Lee, BH
本研究探讨了长期给予槲皮素对大鼠肝脏脂质过氧化和谷胱甘肽含量的影响。雄性SD大鼠被分成两组，一组喂普通饲料，另一组喂不含维生素E的食物。每组又分成三个亚组，分别以2 mg/d、20 mg/d或赋形剂口服治疗4周。治疗后，血清和肝脏中的α-生育酚浓度增加，而服用不含维生素E的饮食的大鼠，这种增加明显更大。槲皮素显著降低肝脏中丙二醛(脂质过氧化的指标)的浓度，这种下降在缺乏维生素E的大鼠中比在正常饮食中维持的大鼠更明显(丙二醛浓度分别下降55-60%和25-35%)。在维生素E缺乏和未剥夺的大鼠中，槲皮素处理显著降低了肝脏中的谷胱甘肽浓度和谷胱甘肽还原酶活性(分别为40%和34%)，其程度相似。综上所述，这些结果表明，在老鼠体内，槲皮素可能不仅是一种抗氧化剂，还可能是一种促氧化剂。(C)2003爱思唯尔B.V.保留所有权利。
The present study was performed to investigate the effects of chronic administration of quercetin on lipid peroxidation and glutathione concentration in rat liver. Male Sprague-Dawley rats were divided into two groups, one of which was fed a normal diet and the other a vitamin E-free diet. Each of these groups was divided further into three subgroups and treated with quercetin administered orally at either 2 or 20 mg/day or with vehicle for 4 weeks. The concentrations of alpha-tocopherol in serum and liver increased following quercetin treatment, and these increases were significantly greater in rats maintained on a vitamin E-free diet. Quercetin significantly decreased the concentration of malondialdehyde (an indicator of lipid peroxidation) in the liver and this decrease was more pronounced in vitamin E-deprived rats than in those maintained on a normal diet (55-60% and 25-35% decrease in malondialdehyde concentrations, respectively). Quercetin treatment decreased the glutathione concentration and glutathione reductase activity (40 and 34%, respectively) in the liver significantly and to a similar extent in vitamin E-deprived and -undeprived rats. Collectively, these results suggest that quercetin may act not only as an antioxidant, but also as a prooxidant in rats. (C) 2003 Elsevier B.V. All rights reserved.