Preparation of interpenetrating networks of gelatin and dextran as degradable biomaterials
Preparation of interpenetrating networks of gelatin and dextran as degradable biomaterials
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DOI：
10.1016/s0142-9612(00)00057-0
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发表时间：
2000-10-01
期刊：
影响因子：
14
通讯作者：
Brannon-Peppas, L
中科院分区：
文献类型：
--
作者：
Kosmala, JD;Henthorn, DB;Brannon-Peppas, L
将明胶和右旋糖酐共混交联形成酶可降解的互穿聚合物网络（IPN），作为可降解植入材料。研究了几种交联方法，包括用甘油醛处理、热硬化和二价金属阳离子螯合葡聚糖。用平衡溶胀法对IPN进行了表征。明胶/葡聚糖IPN在25 ℃下稳定，并达到峰值体积平衡溶胀比高达17，峰值重量溶胀比高达15。当在37摄氏度下溶胀时，凝胶溶解，这表明网络是通过物理交联而不是化学交联形成的。(C)2000爱思唯尔科技有限公司版权所有。
Gelatin and dextran were blended and crosslinked to form enzymatically degradable interpenetrating polymeric networks (IPNs) as materials for degradable implants. Several crosslinking methods were investigated including treatment with glyceraldehyde, thermal hardening, and chelation of dextran by divalent metal cations. IPNs were characterized by an equilibrium swelling method. Gelatin/dextran IPNs were stable at 25 degrees C and reached peak volume equilibrium swelling ratios up to 17 and peak weight swelling ratios up to 15. When swollen at 37 degrees C, the gels dissolved denoting that a network had been formed by physical and not chemical crosslinks. (C) 2000 Elsevier Science Ltd. All rights reserved.