EVIDENCE FOR ACTIVE IMMUNITY TO MORPHINE IN MICE

EVIDENCE FOR ACTIVE IMMUNITY TO MORPHINE IN MICE
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DOI:
10.1126/science.178.4067.1290
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发表时间:
1972-01-01
期刊:
影响因子:
56.9
通讯作者:
SPECTOR, S
SPECTOR, S
中科院分区:
综合性期刊1区
文献类型:
--
作者:
BERKOWITZ, B;SPECTOR, S

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用吗啡免疫原主动免疫小鼠的血清中含有能结合二氢吗啡的抗体。吗啡对这些“免疫”小鼠的影响减弱,血浆中吗啡的浓度也发生了改变。
The serum from mice actively immunized with a morphine immunogen contained antibodies that could bind dihydromorphine. Morphine effects were diminished in these "immunized" mice, and the concentration of morphine in their plasma was altered.