The interaction between intestinal microenvironment and stroke.
The interaction between intestinal microenvironment and stroke.
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DOI：
10.1111/cns.14275
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发表时间：
2023-06
影响因子：
5.5
通讯作者：
中科院分区：
文献类型：
--
作者：
中风不仅是残疾的主要原因，也是继心脏病和癌症之后的第三大死亡原因。中风导致80%的幸存者永久性残疾。然而，目前该患者人群的治疗选择有限。炎症和免疫反应是公认的中风后发生的主要特征。胃肠道拥有复杂的微生物群落，最大的免疫细胞库，并与大脑形成双向调节的脑肠轴。最近的实验和临床研究强调了肠道微环境与中风之间关系的重要性。多年来，肠道对中风的影响已成为生物学和医学中一个重要的动态研究方向。在这篇综述中，我们描述了肠道微环境的结构和功能，并强调了其与中风的相互关系。此外，我们还讨论了针对中风治疗期间肠道微环境的潜在策略。肠道环境的结构和功能可以影响神经功能和脑缺血的结果。通过靶向肠道微生物群来改善肠道微环境可能是治疗中风的新方向。本文综述了肠道微环境的结构和功能，并强调了其与中风的相互关系。改善肠道微环境可能是治疗中风的潜在策略。
Stroke is not only a major cause of disability but also the third leading cause of death, following heart disease and cancer. It has been established that stroke causes permanent disability in 80% of survivors. However, current treatment options for this patient population are limited. Inflammation and immune response are major features that are well‐recognized to occur after a stroke. The gastrointestinal tract hosts complex microbial communities, the largest pool of immune cells, and forms a bidirectional regulation brain‐gut axis with the brain. Recent experimental and clinical studies have highlighted the importance of the relationship between the intestinal microenvironment and stroke. Over the years, the influence of the intestine on stroke has emerged as an important and dynamic research direction in biology and medicine. In this review, we describe the structure and function of the intestinal microenvironment and highlight its cross‐talk relationship with stroke. In addition, we discuss potential strategies aiming to target the intestinal microenvironment during stroke treatment. The structure and function of the intestinal environment can influence neurological function and cerebral ischemic outcome. Improving the intestinal microenvironment by targeting the gut microbiota may be a new direction in treating stroke. This review describes the structure and function of the intestinal microenvironment and highlight its cross‐talk relationship with stroke. Improving the intestinal microenvironment may be a potential strategy for treating stroke.
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影响因子：
82.9
作者：
Benakis C;Brea D;Caballero S;Faraco G;Moore J;Murphy M;Sita G;Racchumi G;Ling L;Pamer EG;Iadecola C;Anrather J
通讯作者：
Anrather J
影响因子：
4.6
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影响因子：
5.5
作者：
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影响因子：
9.3
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通讯作者：
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24.5
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通讯作者：
Delzenne NM