Increased Angiostatin Levels in Bronchoalveolar Lavage Fluids from ARDS Patients and from Human Volunteers after Lung Instillation of Endotoxin
Increased Angiostatin Levels in Bronchoalveolar Lavage Fluids from ARDS Patients and from Human Volunteers after Lung Instillation of Endotoxin
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肺部灌注内毒素后，ARDS 患者和人类志愿者的支气管肺泡灌洗液中血管抑制素水平升高
DOI：
10.1055/s-0037-1613119
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发表时间：
2002
影响因子：
6.7
通讯作者：
J. Pugin
中科院分区：
文献类型：
--
作者：
R. Lucas;H. Lijnen;A. Suffredini;M. Pepper;K. Steinberg;T. Martin;J. Pugin
Summary Acute respiratory distress syndrome (ARDS) is characterized by a disruption of the alveolar-capillary barrier, due to both an epithelial and an endothelial dysfunction. Whereas epithelial apoptosis seems to be mainly mediated by Fas ligand, the mediators of endothelial damage remain to be identified. Angiostatin, a powerful inhibitor of angiogenesis in vivo, also specifically induces apoptosis in endothelial cells. The concentration of various enzymes that cleave angiostatin from plasminogen was reported to be significantly increased in bronchalveolar lavage (BAL) fluids from patients with ARDS. Therefore, in this study, we investigated whether angiostatin was generated during the pulmonary inflammatory response of both healthy subjects challenged with endobronchial endotoxin and in patients with ARDS. We found significantly elevated angiostatin levels in BAL fluids from patients at risk for and with early ARDS (up to 0.022% and 0.018% of total protein, respectively), as well as in BAL fluids from volunteers treated with endotoxin (up to 1.17% of total protein), as compared to BAL fluids from control patients (<0.005% of total protein). These data suggest that angiostatin may contribute to the endothelial damage observed in ARDS, probably via an increased permeability of the alveolar capillary barrier, allowing for an intra-alveolar processing of its precursor plasminogen.
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影响因子：
11.2
作者：
Wei Wen;M. Moses;D. Wiederschain;J. Arbiser;J. Folkman
通讯作者：
Wei Wen;M. Moses;D. Wiederschain;J. Arbiser;J. Folkman
DOI：
10.1164/ajrccm.160.6.9901117
发表时间：
1999-12-01
影响因子：
24.7
作者：
Greene, KE;Wright, JR;Martin, TR
通讯作者：
Martin, TR
DOI：
10.1164/ajrccm.154.2.8756805
发表时间：
1996-08-01
影响因子：
24.7
作者：
Ricou, B;Nicod, L;Dayer, JM
通讯作者：
Dayer, JM
DOI：
10.1073/pnas.95.10.5579
发表时间：
1998-05-12
影响因子：
11.1
作者：
Claesson-Welsh, L;Welsh, M;Folkman, J
通讯作者：
Folkman, J
DOI：
10.1164/ajrccm.153.6.8665045
发表时间：
1996-06-01
影响因子：
24.7
作者：
Pugin, J;Ricou, B;Martin, TR
通讯作者：
Martin, TR