Differences in Sampling Site on Postmortem Cerebrospinal Fluid Biochemistry: A Preliminary Study
Differences in Sampling Site on Postmortem Cerebrospinal Fluid Biochemistry: A Preliminary Study
复制标题
DOI：
10.1097/paf.0000000000000420
复制
发表时间：
2018-12-01
影响因子：
1
通讯作者：
Tse, Rexson
中科院分区：
文献类型：
--
作者：
Garland, Jack;Philcox, Winston;Tse, Rexson
脑脊液（CSF）通常在死后进行分析。所提出的初步研究比较了用于脊髓周围蛛网膜下腔和脑室间隙的生化分析的死后CSF样本。本研究比较了15对CSF样本，其中通过腰椎穿刺从蛛网膜下腔获得的CSF与从脑室获得的CSF相比，钠和氯化物水平较高，镁和钾水平较低。这些差异与死者的年龄显著相关，与死亡时间有相似的趋势。这项研究表明，从不同的收集地点的CSF有不同的电解质浓度，这是年龄和可能的死后时间依赖。采集CSF时，病理学家应记录采集部位、年龄和死后间隔，应避免混合不同部位的CSF样本。进一步的研究是必要的，以澄清其他可能的原因来解释所观察到的差异。
Cerebrospinal fluid (CSF) is often analyzed at postmortem. The presented preliminary study compared postmortem CSF samples for biochemical analysis from the subarachnoid space around the spinal cord and ventricular space of the brain. This study compared 15 paired CSF samples in which the CSF from the subarachnoid space via lumbar puncture had higher sodium and chloride levels and lower magnesium and potassium levels than CSF from the ventricles. The differences correlated significantly with the deceased's age and had a similar trend with postmortem interval. This study suggests that CSF from different collection sites has different electrolyte concentrations, which are age and possibly postmortem interval dependent. When collecting CSF, the pathologist should document the collection site, age, and postmortem interval, and the mixing of CSF samples from different sites should be avoided. Further studies are warranted to clarify other possible reasons to explain the observed differences.