Synergetic effects of subgroup J avian leukosis virus and reticuloendotheliosis virus co-infection on growth retardation and immunosuppression in SPF chickens
Synergetic effects of subgroup J avian leukosis virus and reticuloendotheliosis virus co-infection on growth retardation and immunosuppression in SPF chickens
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DOI：
10.1016/j.vetmic.2014.06.025
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发表时间：
2014-08-27
影响因子：
3.3
通讯作者：
Cui, Zhizhong
中科院分区：
文献类型：
--
作者：
Dong, Xuan;Ju, Sidi;Cui, Zhizhong
为了进一步了解J亚群禽白血病病毒(ALV-J)和网状内皮组织增生症病毒(REV)混合感染SPF白来航鸡的效果，本试验研究了新城疫病毒(NDV)和禽流感病毒H9亚型(AIV-H9)疫苗对SPF白来航鸡的致病性、体重和免疫器官的影响。将雏鸡随机分为4组，即注射组(REV、ALV-J、REV+ALV-J)和阴性对照组。致病试验表明，REV和ALV-J混合感染的雏鸡死亡率显著高于REV或ALV-J单独感染的雏鸡(P<；0.05)。接种REV和ALV-J的雏鸡体重显著低于其他组(P<；0.05)。两个单独感染组和混合感染组的法氏囊和胸腺重量比差异不显著(P>；0.05)，但REV和ALV-J混合感染的雏鸡免疫后新城疫和禽流感的HI抗体效价显著低于REV和ALV-J感染的雏鸡(P<；0.05)。这些结果表明，REV和ALV-J混合感染对SPF鸡造成更严重的生长迟缓和免疫抑制。(C)2014爱思唯尔B.V.保留所有权利。
To further understand the effect of co-infection of subgroup J avian leukosis virus (ALV-J) and reticuloendotheliosis virus (REV) in specific-pathogen-free (SPF) white leghorn chickens, the experiment was made to study the pathogenicity, the weight of body and immune organs, response to newcastle disease virus (NDV) and avian influenza virus subtype H9 (AIV-H9) vaccination. Chickens were randomly divided into four groups, which includes injection groups (REV, ALV-J, REV plus ALV-J), and negative control group. The pathogenesis experiments indicated that chickens co-infected with REV and ALV-J had significantly higher mortality rate than those of the chickens infected with REV or ALV-J alone (P < 0.05). Chickens inoculated with REV and ALV-J had significantly lower weights than chickens in all other groups (P < 0.05). There were no significant differences between the two single infection groups and co-infection group (P > 0.05) on bursa and thymus over body wt ratios, however, chickens co-infected with REV and ALV-J had significantly lower titers than REV-infected chickens and ALV-J-infected chickens on HI antibody titers to ND and AIV-H9 after vaccination (P < 0.05). These findings suggested that the co-infection of REV and ALV-J caused more serious growth retardation and immunosuppression in SPF chickens. (C) 2014 Elsevier B.V. All rights reserved.