T1ρ-based dynamic glucose-enhanced (DGEρ) MRI at 3 T: method development and early clinical experience in the human brain
T1ρ-based dynamic glucose-enhanced (DGEρ) MRI at 3 T: method development and early clinical experience in the human brain
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DOI：
10.1002/mrm.27857
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发表时间：
2019-11-01
影响因子：
3.3
通讯作者：
Zaiss, Moritz
中科院分区：
文献类型：
--
作者：
Herz, Kai;Lindig, Tobias;Zaiss, Moritz
目的：本研究的目的是将基于 T-1 rho 的动态葡萄糖增强 (DGE) 实验从超高磁场强度转化为 3 T 的临床场强。虽然该协议看起来像钆增强成像一样简单，但必须解决几个障碍，包括信噪比 (SNR)、对比度的稳健性和后处理，特别是运动校正。方法：基于自旋锁的预饱和和 3D梯度回波快照读数在鲁棒性、化学交换饱和转移效应强度和信噪比方面针对 3 T 进行了优化。对 7 名健康志愿者的后处理步骤（包括动态 B-0 和运动校正）进行了分析和优化。最终方案（包括葡萄糖注射）应用于 3 名胶质母细胞瘤患者。结果：通过适当的后处理，可以大大减少与运动相关的伪影，并且单次动态测量可以实现约 90 的 SNR。在 2 名血脑屏障破坏的患者中，可以观察到显着的葡萄糖摄取，DGE rho 效应强度在水信号的 0.4% 范围内。对可能的残余运动的彻底分析表明，当针对未校正运动引起的伪效应进行测试时，统计证据可能会减少。结论：DGE rho 成像针对 3 T 的临床场强进行了优化，并为更广泛的应用建立了稳健的协议。早期经验表明，DGE rho 在 3 T 下似乎是可能的，并且不仅仅归因于运动伪影。观察到的 DGE rho 图显示出独特的模式，部分与 T-1-ce 肿瘤环增强相匹配。然而，效果较小，临床应用需谨慎。
Purpose: The aim of this study was to translate the T-1 rho-based dynamic glucose-enhanced (DGE.) experiment from ultrahigh magnetic field strengths to a clinical field strength of 3 T. Although the protocol would seem to be as simple as gadolinium-enhanced imaging, several obstacles had to be addressed, including signal-to-noise ratio (SNR), robustness of contrast, and postprocessing, especially motion correction.Methods: Spin-lock based presaturation and a 3D gradient-echo snapshot readout were optimized for 3 T with regard to robustness, chemical exchange saturation transfer effect strength, and SNR. Postprocessing steps, including dynamic B-0 and motion correction, were analyzed and optimized in 7 healthy volunteers. The final protocol, including glucose injection, was applied to 3 glioblastoma patients.Results: With appropriate postprocessing, motion-related artifacts could be drastically reduced, and an SNR of approximately 90 could be achieved for a single dynamic measurement. In 2 patients with blood-brain barrier breakdown, a significant glucose uptake could be observed with a DGE rho effect strength in the range of 0.4% of the water signal. Thorough analysis of possible residual motion revealed that the statistical evidence can decrease when tested against pseudo effects attributed to uncorrected motion.Conclusion: DGE rho imaging was optimized for clinical field strengths of 3 T, and a robust protocol was established for broader application. Early experience shows that DGE rho seems possible at 3 T and could not only be attributed to motion artifacts. Observed DGE rho maps showed unique patterns, partly matching with the T-1-ce tumor ring enhancement. However, effect sizes are small and careful clinical application is necessary.