Dementia in Parkinson's disease
Dementia in Parkinson's disease
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DOI：
10.1097/wco.0b013e3283168df0
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发表时间：
2008-12-01
影响因子：
4.8
通讯作者：
Kurz, Martin W.
中科院分区：
文献类型：
--
作者：
Aarsland, Dag;Beyer, Mona K.;Kurz, Martin W.
综述目的认知障碍和痴呆是帕金森病最常见的非运动改变。这篇综述的目的是介绍帕金森病痴呆的临床和神经生物学方面的最新研究结果。最近的发现提出了帕金森病痴呆临床诊断的新的共识标准。在两个独立的长期队列研究中，帕金森病患者痴呆的累积患病率非常高。轻度认知障碍甚至发生在早期帕金森病中，并且与较短的痴呆时间相关。来自病理学的新证据，以及在遗传学、成像和脑脊液研究中使用新技术的体内研究表明，α-突触核蛋白聚集和其他候选蛋白的干扰与帕金森病中的痴呆相关。临床、病理和电生理学研究支持帕金森病痴呆不同亚型的假说，可能与不同的潜在脑变化有关。摘要认知能力下降和帕金森病痴呆的潜在机制已经实现。这将有望导致新的治疗方法，通过影响这些机制来预防或延迟痴呆症的发作。
Purpose of reviewCognitive impairment and dementia are among the most common nonmotor changes in Parkinson's disease. The purpose of this review is to present recent findings of clinical and neurobiological aspects of dementia in Parkinson's disease.Recent findingsNew consensus criteria for a clinical diagnosis of dementia in Parkinson's disease have been proposed. A very high cumulative prevalence of dementia in Parkinson's disease has been shown in two independent long-term cohorts. Mild cognitive impairment occurs even in early Parkinson's disease and is associated with a shorter time to dementia. Emerging evidence from pathology, as well as in-vivo studies using novel techniques within genetics, imaging, and cerebrospinal fluid research, indicates that alpha-synuclein aggregation and disturbances of other candidate proteins are associated with dementia in Parkinson's disease. Clinical, pathological, and electrophysiological studies support the hypothesis of different subtypes of dementia in Parkinson's disease, potentially related to different underlying brain changes.Summary Increased understanding of underlying mechanisms of cognitive decline and dementia in Parkinson's disease has been achieved. This will hopefully lead to novel treatment with the potential of preventing or delaying the onset of dementia by influencing these mechanisms.