Enantioselective, Catalytic Trichloromethylation through Visible-Light-Activated Photoredox Catalysis with a Chiral Iridium Complex
Enantioselective, Catalytic Trichloromethylation through Visible-Light-Activated Photoredox Catalysis with a Chiral Iridium Complex
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DOI：
10.1021/jacs.5b06010
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发表时间：
2015-08-05
影响因子：
15
通讯作者：
Meggers, Eric
中科院分区：
文献类型：
--
作者：
Huo, Haohua;Wang, Chuanyong;Meggers, Eric
报道了2-酰基咪唑和2-酰基吡啶的对映选择性催化三氯甲基化反应。形成对映体过量>= 99%的几种产物。在该体系中，手性铱络合物具有双重功能，作为催化活性的手性刘易斯酸，同时作为原位组装的可见光触发的光氧化还原催化剂的前体。
An enantioselective, catalytic trichloromethylation of 2-acyl imidazoles and 2-acylpyridines is reported. Several products are formed with enantiomeric excess of >= 99%. In this system, a chiral iridium complex serves a dual function, as a catalytically active chiral Lewis acid and simultaneously as a precursor for an in situ assembled visible-light-triggered photoredox catalyst.