ERYTHROCYTE-P ANTIGEN - CELLULAR RECEPTOR FOR B19 PARVOVIRUS
ERYTHROCYTE-P ANTIGEN - CELLULAR RECEPTOR FOR B19 PARVOVIRUS
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DOI：
10.1126/science.8211117
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发表时间：
1993-10-01
期刊：
影响因子：
56.9
通讯作者：
YOUNG, NS
中科院分区：
文献类型：
--
作者：
BROWN, KE;ANDERSON, SM;YOUNG, NS
致病性人细小病毒B19仅在红系祖细胞中复制。经血凝测定，该病毒可与血型P抗原结合。缺乏P抗原的红细胞不能与B19凝集。在造血集落试验中，纯化的P抗原（糖苷）阻断了病毒与红细胞的结合和病毒的传染性。用单克隆抗体对靶细胞进行预孵育，保护靶细胞免受感染。了解细小病毒受体对理解细小病毒感染的发病机制和在基因治疗中使用细小病毒具有重要意义。
The pathogenic human parvovirus B19 replicates only in erythroid progenitor cells. This virus was shown to bind to blood-group P antigen, as measured by hemagglutination. Erythrocytes lacking P antigen were not agglutinated with B19. Purified P antigen (globoside) blocked the binding of the virus to erythroid cells and the infectivity of the virus in a hematopoietic colony assay. Target cells were protected from infection by preincubation with monoclonal antibody to globoside. Knowledge of a parvovirus receptor has implications for understanding the pathogenesis of parvovirus infections and for the use of parvoviruses in gene therapy.