Weight stability masks sarcopenia in elderly men and women
Weight stability masks sarcopenia in elderly men and women
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DOI：
10.1152/ajpendo.2000.279.2.e366
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发表时间：
2000-08-01
影响因子：
5.1
通讯作者：
Heymsfield, SB
中科院分区：
文献类型：
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作者：
Gallagher, D;Ruts, E;Heymsfield, SB
在横断面研究中，骨骼肌损失或肌肉减少已被提出，但在使用适当的测量技术结合纵向研究设计的老年受试者中尚未显示。在独立生活的健康男性（n = 24）和女性（n = 54，平均年龄73岁）中，研究了60岁后骨骼肌质量的纵向变化，平均+/- SD随访时间为4.7 +/- 2.3年。测量包括区域骨骼肌质量，四个额外的瘦成分（无脂体质量，身体细胞质量，全身总水分和骨矿物质）和全身总脂肪。男性阑尾骨骼肌（TSM）总质量下降（-0.8 +/- 1.2 kg, P = 0.002），包括腿部骨骼肌（LSM）减少（-0.7 +/- 0.8 kg, P = 0.001）和手臂骨骼肌减少（ASM, -0.2 +/- 0.4 kg, P = 0.06）。在女性中，TSM质量下降（-0.4 +/- 1.2 kg, P = 0.006），包括LSM减少（-0.3 +/- 0.8 kg, P = 0.005）和ASM减少的趋势（-0.1 +/- 0.6 kg, P = 0.20）。多元回归模型显示男性的LSM丧失率更高。随访期间男性体重无显著变化（-0.5 +/- 3.0 kg, P = 0.44），脂肪量增加（+1.2 +/- 2.4 kg, P = 0.03）。女性的体重和脂肪量没有显著降低（20.8 +/- 3.9 kg, P = 0.15和20.8 +/- 3.5 kg, P = 0.12）。这些观察结果表明，肌肉减少症是一个渐进的过程，特别是在老年男性中，甚至发生在健康独立生活的老年人中，他们可能没有表现出体重减轻。
Skeletal muscle loss or sarcopenia in aging has been suggested in cross-sectional studies but has not been shown in elderly subjects using appropriate measurement techniques combined with a longitudinal study design. Longitudinal skeletal muscle mass changes after age 60 yr were investigated in independently living, healthy men (n = 24) and women (n = 54; mean age 73 yr) with a mean +/- SD follow-up time of 4.7 +/- 2.3 yr. Measurements included regional skeletal muscle mass, four additional lean components (fat-free body mass, body cell mass, total body water, and bone mineral), and total body fat. Total appendicular skeletal muscle (TSM) mass decreased in men (-0.8 +/- 1.2 kg, P = 0.002), consisting of leg skeletal muscle (LSM) loss (-0.7 +/- 0.8 kg, P = 0.001) and a trend toward loss of arm skeletal muscle (ASM; -0.2 +/- 0.4 kg, P = 0.06). In women, TSM mass decreased (-0.4 +/- 1.2 kg, P = 0.006) and consisted of LSM loss (-0.3 +/- 0.8 kg, P = 0.005) and a tendency for a loss of ASM (-0.1 +/- 0.6 kg, P = 0.20). Multiple regression modeling indicates greater rates of LSM loss in men. Body weight in men at follow-up did not change significantly (-0.5 +/- 3.0 kg, P = 0.44) and fat mass increased (+1.2 +/- 2.4 kg, P = 0.03). Body weight and fat mass in women were nonsignificantly reduced (20.8 +/- 3.9 kg, P = 0.15 and 20.8 +/- 3.5 kg, P = 0.12). These observations suggest that sarcopenia is a progressive process, particularly in elderly men, and occurs even in healthy independently living older adults who may not manifest weight loss.