Block of conduction in mammalian myelinated nerve fibres by low temperatures.
Block of conduction in mammalian myelinated nerve fibres by low temperatures.
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低温阻碍哺乳动物有髓神经纤维的传导。
DOI：
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发表时间：
1965
期刊：
影响因子：
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通讯作者：
A. Paintal
中科院分区：
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作者：
A. Paintal
低温被广泛用于阻断各种呼吸和心血管反射，因为低温对不同直径的神经纤维有不同的影响。然而，关于这种差异效应的性质，没有一致的意见（Paintal，1963年）。一组研究以复合动作电位为指导，表明较小的有髓纤维在比阻断较大纤维传导所需的温度更高的温度下被阻断（Dodt，1953;道格拉斯和马尔科姆，1955）。另一方面，托兰斯和惠特里奇（1948）、惠特里奇（1948）和威迪科姆（1954）记录了单个纤维的冲动，得出了相反的结论。最近，通过比较肺传入纤维的阻滞温度分布与其传导速度分布，获得了对后一结论的一些支持（参见图1）。图8，载于Paintal，1963年）。实验开始时，人们期望这一结论很容易得到证实，但正如本文所示，有髓神经纤维的传导速度与其阻断温度之间没有关系。在下面的论文中，将介绍不同温度对神经纤维传导的影响的系统研究结果（Paintal，1965）。
Low temperatures are used extensively for blocking various respiratory and cardiovascular reflexes on the presumption that cold must have a differential effect on the nerve fibres of different diameters. However, there is no unanimity of opinion regarding the nature of this differential effect (Paintal, 1963). One group of studies, in which the compound action potential has been used as a guide, has indicated that the smaller myelinated fibres are blocked at a higher temperature than that needed to block conduction in the larger fibres (Dodt, 1953; Douglas & Malcolm, 1955). On the other hand, Torrance & Whitteridge (1948), Whitteridge (1948), and Widdicombe (1954), who recorded impulses in individual fibres, have arrived at the opposite conclusion. Some support for the latter conclusion was obtained recently by comparing the distribution of the blocking temperatures of pulmonary afferent fibres with the distribution of their conduction velocities (cf. Fig. 8 in Paintal, 1963). Experiments were begun with the expectation that this conclusion would be easily confirmed but it turns out, as shown in this paper, that there is no relation between the conduction velocities of myelinated nerve fibres and their blocking temperatures. In the following paper, the results of a systematic study of the effects of different temperatures on conduction in nerve fibres will be presented (Paintal, 1965).