Enhanced up/down-conversion luminescence and heat: Simultaneously achieving in one single core-shell structure for multimodal imaging guided therapy
Enhanced up/down-conversion luminescence and heat: Simultaneously achieving in one single core-shell structure for multimodal imaging guided therapy
复制标题
增强的上/下转换发光和热：在一个核壳结构中同时实现多模态成像引导治疗
DOI：
10.1016/j.biomaterials.2016.07.031
复制
发表时间：
2016-10-01
期刊：
影响因子：
14
通讯作者：
Lin, Jun
中科院分区：
文献类型：
--
作者：
He, Fei;Feng, Lili;Lin, Jun
近红外（NIR）光照射下，Nd ~（3+）掺杂引起的近红外区下转换发光（DCL）和热效应在生物成像和光热治疗（PTT）等领域具有重要的应用价值。然而，浓度猝灭导致这两种性质的相反变化趋势，使得难以在单个颗粒中同时获得所需的DCL和热效应。本研究首先设计了一种独特的NaGdF 4：0.3%Nd@NaGdF4@NaGdF4：10%Ybi1%Er@NatdF（4）：10%Yb@NaNdF4：10%Yb多核壳结构。在808 nm光激发下，两层惰性层（NaGdF 4和NaGdF 4：10%Yb）可以基本消除猝灭效应，从而同时实现显著增强的NIR-至-NIR DCL、NIR-至-维斯上转换发光（UCL）和热效应。UCL激发附着的光敏药物（Au-25纳米团簇）以产生用于光动力疗法（PDT）的单线态氧（102），而具有强NIR发射的DCL用作用于敏感的深部组织成像的探针。体外和体内实验结果表明，由于PTT和PDT的组合产生的协同效应，该平台具有优异的癌症抑制功效。此外，还获得了包括荧光成像（FI）、光热成像（PTI）和光声成像（派）在内的多模态成像，用于监测药物输送过程、肿瘤内部结构和光治疗过程，从而实现成像引导的癌症治疗目标。(C)2016爱思唯尔有限公司版权所有
Upon near-infrared (NIR) light irradiation, the Nd3+ doping derived down-conversion luminescence (DCL) in NIR region and thermal effect are extremely fascinating in bio-imaging and photothermal therapy (PTT) fields. However, the concentration quenching induced opposite changing trend of the two properties makes it difficult to get desired DCL and thermal effect together in one single particle. In this study, we firstly designed a unique NaGdF4:0.3%Nd@NaGdF4@NaGdF4:10%Ybi1%Er@NatdF(4):10%Yb @NaNdF4:10%Yb multiple core-shell structure. Here the inert two layers (NaGdF4 and NaGdF4:10%Yb) can substantially eliminate the quenching effects, thus achieving markedly enhanced NIR-to-NIR DCL, NIR-to-Vis up-conversion luminescence (UCL), and thermal effect under a single 808 nm light excitation simultaneously. The UCL excites the attached photosensitive drug (Au-25 nanoclusters) to generate singlet oxygen (102) for photodynamic therapy (PDT), while DCL with strong NIR emission serves as probe for sensitive deep-tissue imaging. The in vitro and in vivo experimental-results demonstrate the excellent cancer inhibition efficacy of this platform due to a synergistic effect arising from the combined PTT and PDT. Furthermore, multimodal imaging including fluorescence imaging (FI), photothermal imaging (PTI), and photoacoustic imaging (PAI) has been obtained, which is used to monitor the drug delivery process, internal structure of tumor and photo-therapeutic process, thus achieving the target of imaging-guided cancer therapy. (C) 2016 Elsevier Ltd. All rights reserved.