CHARACTERIZATION OF CHROMOSOMAL-ANOMALIES IN HUMAN BREAST-CANCER - A COMPARISON OF 30 PARADIPLOID CASES WITH FEW CHROMOSOME CHANGES
CHARACTERIZATION OF CHROMOSOMAL-ANOMALIES IN HUMAN BREAST-CANCER - A COMPARISON OF 30 PARADIPLOID CASES WITH FEW CHROMOSOME CHANGES
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DOI：
10.1016/0165-4608(90)90143-x
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发表时间：
1990-10-15
影响因子：
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通讯作者：
ZAFRANI, B
中科院分区：
文献类型：
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作者：
DUTRILLAUX, B;GERBAULTSEUREAU, M;ZAFRANI, B
本文报告30例近二倍体女性乳腺癌染色体异常的比较。在118例样本中，选择了核型复杂性相对较低的肿瘤，其中20例以前未发表。几乎所有的151个结构重排检测不平衡，67%的断裂点位于异染色质或与异染色质接触。在少数异常的情况下，1号和/或16号染色体的重排非常频繁，主要导致1 q的增加和16 q的丢失。在有更多异常的病例中（5-16），涉及17 p，4p，13，6 q，8 p，9 p，11 p和11 q的缺失以及1 q和8 q的增加是最常见的。在14例肿瘤中检测到HSR，主要位于染色体8 p（6/22）和19（3/22）。未观察到双分钟（dmin）。我们的结论是，三体1 q和单体16 q是乳腺癌的早期染色体变化，而其他缺失和获得的8 q显然是次要事件。
A comparison of chromosomal anomalies detected in 30 cases of breast cancer in females with near-diploid karyotypes is reported. The tumors, of which 20 were previously unpublished, were selected for the relatively low complexity of their karyotypes, among a sample of 118 cases. Almost all of the 151 structural rearrangements detected were unbalanced, and 67% of breakpoints were located in or had contact with heterochromatin. In cases with few anomalies, rearrangements of chromosomes 1 and/or 16 were very frequent, leading principally to a gain of 1q and loss of 16q. In cases with more anomalies (5-16), deletions involving 17p, 4p, 13, 6q, 8p, 9p, 11p, and 11q and gains of 1q and 8q were the most frequent. Homogeneously staining regions (HSR) were detected in 14 tumors, mostly on 8p (6/22) and chromosome 19 (3/22). No double minutes (dmin) were observed. We concluded that trisomy 1q and monosomy 16q are early chromosomal changes in breast cancer, whereas other deletions and gain of 8q are clearly secondary events.