Long non-coding RNA DIO3OS binds to microRNA-130b to restore radiosensitivity in esophageal squamous cell carcinoma by upregulating PAX9 (Retracted Article)
Long non-coding RNA DIO3OS binds to microRNA-130b to restore radiosensitivity in esophageal squamous cell carcinoma by upregulating PAX9 (Retracted Article)
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DOI：
10.1038/s41417-021-00344-2
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发表时间：
2021-06-28
影响因子：
6.4
通讯作者：
Zhao, Di
中科院分区：
文献类型：
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作者：
Liu, Junqi;Zhou, Runze;Zhao, Di
Esophageal squamous cell carcinoma (ESCC) ranks as one of the most deadly cancers worldwide due to its aggressive progression and poor treatment response. The long non-coding RNA (lncRNA)-microRNA (miRNA)-messenger RNA (mRNA) axis has been highlighted as a potency biomarker for enhancing the radiosensitivity of ESCC. Hence, we investigated the functional mechanism of the lncRNA DIO3OS/miR-130b/PAX9 axis in the radioresistance of ESCC cells. In cell experiments, we altered the miR-130b expression in ESCC cells using mimic or inhibitor to examine its effects on ESCC cell activities in response to 4 Gy irradiation, as well testing the involvement of lncRNA DIO3OS and the transcription factor gene PAX9. Tumor xenograft experiments were then conducted to observe the effect of miR-130b, lncRNA DIO3OS, and PAX9 on the radiosensitivity of ESCC cells in vivo. miR-130b was found to be highly expressed in ESCC. Downregulated miR-130b inhibited proliferation, invasion, and resistance to apoptosis in ESCC cells. LncRNA DIO3OS and PAX9 were downregulated in ESCC. The lncRNA DIO3OS could upregulate PAX9 by binding to miR-130b, which ultimately promoted the radiosensitivity of ESCC in vitro and in vivo. Taken together, lncRNA DIO3OS upregulates the expression of PAX9 by binding to miR-130b, ultimately promoting the radiosensitivity of ESCC.
