Faithful companions: A proposal for neurooncology trials in pet dogs
Faithful companions: A proposal for neurooncology trials in pet dogs
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DOI：
10.1158/0008-5472.can-06-3792
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发表时间：
2007-05-15
期刊：
影响因子：
11.2
通讯作者：
Nalbantoglu, Josephine
中科院分区：
文献类型：
--
作者：
Kimmelman, Jonathan;Nalbantoglu, Josephine
尽管相对罕见，恶性胶质瘤（MG）经常被用于测试新的癌症治疗方法。然而，人类IVIG试验通常是在临床前模型的基础上启动的，其中涉及与人类疾病的许多不连续性。下面，我们将讨论用于MG临床前研究的主要模型，即小鼠原位异种移植物的各种局限性。在讨论了转基因小鼠模型和犬异种移植等替代模型系统后，我们认为患有自发性脑癌的伴侣动物为新型MG干预措施的临床前测试提供了科学和伦理上有吸引力的系统。简要讨论了伴侣动物脑癌试验的伦理优势和现实挑战。
Although relatively rare, malignant glioma (MG) is frequently used for testing novel cancer treatments. However, human IVIG trials have often been initiated on the basis of preclinical models that involve numerous discontinuities with the human disease. Below, we discuss various limitations of the mainstay model used in MG preclinical research, the murine orthotopic xenograft. After discussing alternative model systems like transgenic mouse models and canine xenografts, we argue that companion animals with spontaneous brain cancers offer a scientifically and ethically attractive system for preclinical testing of novel MG interventions. Ethical advantages and practical challenges of companion animal brain cancer trials are briefly discussed.