What is memory? The present state of the engram.
What is memory? The present state of the engram.
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DOI：
10.1186/s12915-016-0261-6
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发表时间：
2016-05-19
期刊：
影响因子：
5.4
通讯作者：
Stevens C
中科院分区：
文献类型：
--
作者：
Poo MM;Pignatelli M;Ryan TJ;Tonegawa S;Bonhoeffer T;Martin KC;Rudenko A;Tsai LH;Tsien RW;Fishell G;Mullins C;Gonçalves JT;Shtrahman M;Johnston ST;Gage FH;Dan Y;Long J;Buzsáki G;Stevens C
记忆的机制仍然是生物学中尚未解决的重大问题之一。一百多年前，德国动物学家理查德·塞蒙在与这个问题的斗争中提出了印记的概念，印记是大脑中持久的连接，由同时的“兴奋”产生，其确切的物理性质和后果是他那个时代的生物学无法企及的。然而，神经科学家现在有了解决这个问题的知识和工具，这个论坛汇集了当代关于记忆机制和记忆记忆的意义的领先观点。
The mechanism of memory remains one of the great unsolved problems of biology. Grappling with the question more than a hundred years ago, the German zoologist Richard Semon formulated the concept of the engram, lasting connections in the brain that result from simultaneous “excitations”, whose precise physical nature and consequences were out of reach of the biology of his day. Neuroscientists now have the knowledge and tools to tackle this question, however, and this Forum brings together leading contemporary views on the mechanisms of memory and what the engram means today.