Continuous compact protein domains.
Continuous compact protein domains.
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连续紧凑的蛋白质结构域。
DOI：
10.1002/prot.340020204
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发表时间：
1987
期刊：
影响因子：
2.9
通讯作者：
Zehfus,MH
中科院分区：
文献类型：
--
作者：
Zehfus,MH
最近引入了紧凑系数，并用于定位溶菌酶和核糖核酸酶中的结构域（Zehfus和Rose：Biochemistry 25：5759-5765，1986）。现在已经用这种方法分析了另外19种蛋白质。提供了所有21种蛋白质的紧凑单元的完整列表和显示其层次结构的图。大的紧凑单元很好地对应于蛋白质结构域;然而，也发现了许多具有相同或更好紧凑性的较小紧凑结构。由于小的紧凑单元可以代表子域或蛋白质折叠中间体，因此它们的结构组成被进一步研究。
The coefficient of compactness was recently introduced and used to locate domains in lysozyme and ribonuclease (Zehfus and Rose:Bio‐chemistry25:5759–5765, 1986). Nineteen additional proteins now have been analyzed by using this measure. Complete listings of compact units and plots showing their hierarchic organization are presented for all twenty‐one proteins. Large compact units correspond well to protein domains; however, many smaller compact structures of equal or better compactness are also found. Since small compact units could represent subdomains or protein‐folding intermediates, their structural composition is further examined.