Brain metastasis: Unique challenges and open opportunities.
Brain metastasis: Unique challenges and open opportunities.
复制标题
脑转移：独特的挑战和开放的机会。
DOI：
10.1016/j.bbcan.2016.12.001
复制
发表时间：
2017-01
期刊：
影响因子：
--
通讯作者：
Yu D
中科院分区：
文献类型：
--
作者：
Lowery FJ;Yu D
癌症向中枢神经系统（CNS）的转移仍然是一个毁灭性的临床现实，尽管最近针对其他疾病背景的治疗取得了突破，但估计存活时间不到一年。脑转移研究的进展受到许多原因的阻碍，包括其复杂的性质和在独特的脑微环境中建模转移性癌症生长的困难。在本文中，我们将讨论临床挑战，并比较脑转移研究可用模型的价值和局限性。此外，我们将专门讨论目前关于脑转移瘤如何利用独特的脑环境来促进自身生长的知识。最后，我们将探讨大脑独特的代谢和营养特征;这些矛盾的障碍是如何建立脑转移的，但也为转移细胞在大脑中的生长提供了充足的供应。我们设想，多学科的创新方法将为该领域在应对脑转移的独特挑战方面取得突破提供机会。
The metastasis of cancer to the central nervous system (CNS) remains a devastating clinical reality, carrying an estimated survival time of less than one year in spite of recent therapeutic breakthroughs for other disease contexts. Advances in brain metastasis research are hindered by a number of reasons, including its complicated nature and the difficulty of modeling metastatic cancer growth in the unique brain microenvironment. In this review, we will discuss the clinical challenge, and compare the values and limitations of the available models for brain metastasis research. Additionally, we will specifically address current knowledge on how brain metastases take advantage of the unique brain environment to benefit their own growth. Finally, we will explore the distinctive metabolic and nutrient characteristics of the brain; how these paradoxically represent barriers to establishment of brain metastasis, but also provide ample supplies for metastatic cells’ growth in the brain. We envision that multi-disciplinary innovative approaches will open opportunities for the field to make breakthroughs in tackling unique challenges of brain metastasis.