Aggregates of silicon quantum dots as a drug carrier: selective intracellular drug release based on pH-responsive aggregation/dispersion
Aggregates of silicon quantum dots as a drug carrier: selective intracellular drug release based on pH-responsive aggregation/dispersion
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DOI：
10.1039/c5cc00925a
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发表时间：
2015-01-01
影响因子：
4.9
通讯作者：
Yamaguchi, Yukio
中科院分区：
文献类型：
--
作者：
Ohta, Seiichi;Yamura, Kentaro;Yamaguchi, Yukio
使用具有可见光致发光的胺修饰硅量子点（Si-QD）作为构建块，组装了载药 Si-QD 聚集体。这些聚集体被设计为响应内体 pH 值降低而分解，从而实现负载药物的选择性细胞内释放。
Using amine-modified silicon quantum dots (Si-QDs) with visible photoluminescence as a building block, drug-loaded Si-QD aggregates were assembled. The aggregates were designed to break down in response to the endosomal pH decrease, which enabled the selective intracellular release of the loaded drugs.