Effects of STN DBS for Parkinson's disease on restless legs syndrome and other sleep-related measures
Effects of STN DBS for Parkinson's disease on restless legs syndrome and other sleep-related measures
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DOI：
10.1016/j.parkreldis.2010.11.017
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发表时间：
2011-03-01
影响因子：
4.1
通讯作者：
Sun, Z.
中科院分区：
文献类型：
--
作者：
Chahine, L. M.;Ahmed, A.;Sun, Z.
不宁腿综合征（RLS）和其他睡眠异常在帕金森病（PD）中很常见。我们前瞻性地检查了接受丘脑底核（DBS）脑深部电刺激（DBS）的PD患者的睡眠指标。通过术前和术后电话访谈进行RLS问卷、埃普沃思嗜睡量表（ESS）和帕金森病睡眠量表（PDSS）。纳入17例患者。平均术前和术后4周ESS评分分别为11.6和6.4（p < 0.001），PDSS评分分别为94.2和122.9（p < 0.001）。改善持续到6个月。6例患者术前诊断为RLS。平均术前国际不宁腿综合征研究组评定量表评分为23.0。术后4周和6个月平均IRLSSG评定量表评分分别为14.8和13.8，与术前评分相比显著改善（分别为p = 0.027和p = 0.037）。无患者术后发生新发RLS。DBS可改善日间嗜睡、睡眠质量和RLS。(C)2010爱思唯尔有限公司保留所有权利。
Restless legs syndrome (RLS) and other sleep abnormalities are common in Parkinson's Disease (PD). We prospectively examined sleep measures in PD patients undergoing subthalamic nucleus (STN) deep brain stimulation (DBS). An RLS questionnaire, Epworth Sleepiness Scale (ESS), and Parkinson's Disease Sleep Scale (PDSS) were administered through telephone interviews preoperatively and postoperatively. Seventeen patients were included. Mean preoperative and 4 weeks postoperative ESS scores were 11.6 and 6.4 respectively (p < 0.001) and PDSS scores were 94.2 and 122.9 respectively (p < 0.001). The improvement was sustained at 6 months. Six patients were diagnosed with RLS preoperatively. Mean preoperative International Restless Legs Syndrome Study Group rating scale score was 23.0. Mean 4 week and 6 month postoperative IRLSSG rating scale scores were 14.8 and 13.8 respectively, significantly improved compared to preoperative scores (p = 0.027 and p = 0.037 respectively). No patients developed new-onset RLS postoperatively. STN DBS improves daytime sleepiness, sleep quality, and RLS. (C) 2010 Elsevier Ltd. All rights reserved.