ABCC2 rs2273697 is associated with valproic acid concentrations in patients with epilepsy on valproic acid monotherapy
ABCC2 rs2273697 is associated with valproic acid concentrations in patients with epilepsy on valproic acid monotherapy
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ABCC2 rs2273697 与丙戊酸单药治疗癫痫患者的丙戊酸浓度相关
DOI：
10.1691/ph.2018.7344
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发表时间：
2018-05-01
期刊：
影响因子：
1.6
通讯作者：
Huang, Min
中科院分区：
文献类型：
--
作者：
Chen, Juan;Su, Qi-Biao;Huang, Min
丙戊酸(VPA)是一种广泛使用的抗癫痫药物，其浓度具有强烈的个体差异。外排转运体和内流转运体在VPA的处置中都起着重要作用，但ABC/SLC家系单核苷酸多态(SNP)与VPA浓度的相关性尚未见报道。在本研究中，我们研究了187例接受VPA单药治疗的中国癫痫患者ABCC2、ABCC4、ABCG2、MCT1、MCT2和OATP2B1的12个SNPs与VPA谷浓度的关系。结果显示，ABCC2rs2273697AA型患者血浆VPA浓度显著高于GA+GG型患者(P=0.000)。本研究结果提示，ABCC2基因多态性影响接受VPA单一治疗的癫痫患者的VPA浓度，这可能影响治疗结果。
Valproic acid (VPA), a widely used antiepileptic drug, is characterized by intensive inter-individual variability in concentration. Both efflux and influx transporters are reported to play important roles in the disposition of VPA, however, no comprehensive investigation into the association of the single nucleotide polymorphism (SNP) in ABC/SLC families with VPA concentration are reported. In the present study, we investigated the association of 12 SNPs in ABCC2,ABCC4,ABCG2, MCT1, MCT2, and OATP2B1 in 187 Chinese patients with epilepsy on VPA monotherapy with the trough concentrations of VPA. The data showed that VPA concentration in patients with ABCC2 rs2273697 AA genotype was significantly higher than that in those with GA+GG genotypes (p=0.000). The findings of the present study suggest that ABCC2 polymorphisms influence VPA concentrations in patients with epilepsy on VPA monotherapy, which may affect the treatment outcomes.