miR-134: A Human Cancer Suppressor?
miR-134: A Human Cancer Suppressor?
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miR-134：人类癌症抑制剂？
DOI：
10.1016/j.omtn.2016.11.003
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发表时间：
2017-03-17
期刊：
影响因子：
--
通讯作者：
Li DJ
中科院分区：
文献类型：
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作者：
Pan JY;Zhang F;Sun CC;Li SJ;Li G;Gong FY;Bo T;He J;Hua RX;Hu WD;Yuan ZP;Wang X;He QQ;Li DJ
microRNA（miRNAs）是一类长度约为20-25 nt的非编码小RNA，通过直接与靶基因的3′ UTR结合发挥重要作用。已有研究表明，miRNAs与包括癌症在内的多种疾病有关。近年来发现miR-134在肺癌、胶质瘤、乳腺癌、结直肠癌等多种肿瘤中表达异常，越来越多的证据表明miR-134在肿瘤的发生、发展、侵袭转移、细胞凋亡、耐药以及肿瘤的诊断、治疗和预后中起重要作用。然而，miR-134在人类肿瘤中的作用仍不明确，其作用机制也很复杂，涉及多种靶点和信号通路，如STAT 5 B、KRAS、MAPK/ERK信号通路、Notch通路等。本文通过分析最新研究成果，综述miR-134在多种人类肿瘤中的重要作用，为癌症的诊断、治疗、预后、或进一步调查。
MicroRNAs (miRNAs) are small noncoding RNAs approximately 20–25 nt in length, which play crucial roles through directly binding to corresponding 3′ UTR of targeted mRNAs. It has been reported that miRNAs are involved in numerous of diseases, including cancers. Recently, miR-134 has been identified to dysregulate in handles of human cancers, such as lung cancer, glioma, breast cancer, colorectal cancer, and so on. Increasing evidence indicates that miR-134 is essential for human carcinoma and participates in tumor cell proliferation, apoptosis, invasion and metastasis, drug resistance, as well as cancer diagnosis, treatment, and prognosis. Nevertheless, its roles in human cancer are still ambiguous, and its mechanisms are sophisticated as well, referring to a variety of targets and signal pathways, such as STAT5B, KRAS, MAPK/ERK signal pathway, Notch pathway, etc. Herein, we review the crucial roles of miR-134 in scores of human cancers via analyzing latest investigations, which might provide evidence for cancer diagnose, treatment, prognosis, or further investigations.