Candida albicans biofilm inactivated by cold plasma treatment in vitro and in vivo
Candida albicans biofilm inactivated by cold plasma treatment in vitro and in vivo
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体外和体内冷等离子体处理灭活白色念珠菌生物膜
DOI：
10.1002/ppap.201900068
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发表时间：
2020-01-08
影响因子：
3.5
通讯作者：
Chen, Hongxiang
中科院分区：
文献类型：
--
作者：
He, Mengwen;Duan, Jiangwei;Chen, Hongxiang
由于抗真菌药物出现耐药性，白色念珠菌引起的真菌感染在世界范围内有所增加，这主要是由生物膜形成引起的。因此，迫切需要一种新的有效的抗菌策略来治疗白色念珠菌生物膜相关感染。在本研究中，在体外和体内评估了冷等离子体处理对白色念珠菌生物膜的灭活效果。体外研究表明，悬浮液中的白色念珠菌和白色念珠菌生物膜通过等离子体处理显着灭活。体内研究表明，血浆治疗在最佳剂量（本例中为4分钟）下可达到最佳抗真菌效果，因为与4分钟组相比，过量血浆治疗会损害正常组织，从而导致感染加重。
Fungal infections induced by Candida albicans have increased worldwide due to emerging resistance to antifungal agents, which is largely caused by biofilm formation. Thus, a new and effective antimicrobial strategy is urgently required in treatment of C. albicans biofilm-associated infections. In this study, the inactivation effects of cold plasma treatment for C. albicans biofilm are assessed in vitro and in vivo. In vitro studies indicate that C. albicans in suspension and the C. albicans biofilm are inactivated significantly by plasma treatment. In vivo studies indicate that plasma treatment achieves the best antifungal effect with an optimal dose (4 min in this case), as excessive plasma treatment damages the normal tissues and thus induces aggravation of infection compared to the 4-min group.