A dielectric affinity microbiosensor
A dielectric affinity microbiosensor
复制标题
DOI：
10.1063/1.3291669
复制
发表时间：
2010-01-18
影响因子：
4
通讯作者：
Lin, Qiao
中科院分区：
文献类型：
--
作者：
Huang, Xian;Li, Siqi;Lin, Qiao
我们提出了一种亲和生物传感方法，利用聚合物的介电性质的变化，由于其特定的，可逆的结合与分析物。该方法是使用微传感器，包括一对薄膜电容性电极的聚（丙烯酰胺-RAN-3-acrylamidophenylboronic acid），一种合成的聚合物，具有特定的亲和力，以葡萄糖的溶液。与葡萄糖的结合诱导聚合物的介电常数的变化，其可以被测量用于特定葡萄糖检测的电容，如通过在生理相关浓度下的实验结果所证实的。介电亲和生物传感方法具有实际应用的潜力，如长期连续葡萄糖监测。
We present an affinity biosensing approach that exploits changes in dielectric properties of a polymer due to its specific, reversible binding with an analyte. The approach is demonstrated using a microsensor comprising a pair of thin-film capacitive electrodes sandwiching a solution of poly(acrylamide-ran-3-acrylamidophenylboronic acid), a synthetic polymer with specific affinity to glucose. Binding with glucose induces changes in the permittivity of the polymer, which can be measured capacitively for specific glucose detection, as confirmed by experimental results at physiologically relevant concentrations. The dielectric affinity biosensing approach holds the potential for practical applications such as long-term continuous glucose monitoring.