Functional difference in short- and long-latency interhemispheric inhibiti on from active to resting hemisphere during a unilateral muscle contraction
Functional difference in short- and long-latency interhemispheric inhibiti on from active to resting hemisphere during a unilateral muscle contraction
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单侧肌肉收缩期间从活动半球到静息半球的短潜伏期和长潜伏期半球间抑制的功能差异
DOI：
10.1152/jn.00494.2013
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发表时间：
2014
影响因子：
2.5
通讯作者：
Kozo Funase
中科院分区：
文献类型：
--
作者：
Kazumasa Uehara;Takuya Mori shita;Shinji Kubota;Masato Hirano;Kozo Funase
本研究的目的是探讨在单侧肌肉收缩过程中，配对脉冲经颅磁刺激从活动到静息的初级运动皮层（M1）的短潜伏期（SIHI）和长潜伏期（LIHI）半球间抑制是否存在功能差异。在9名健康的右撇子参与者中，IHI从主导到非主导M1进行了测试，反之亦然，在休息条件下或在与右侧或左侧第一背侧骨间肌在10%和30%的最大自愿收缩的持续单侧肌肉收缩的性能。为了获得SIHI和LIHI的测量值，在M1对侧肌肉收缩上施加条件刺激（CS），然后在M1同侧肌肉收缩上以短（10 ms）和长（40 ms）的刺激间间隔施加测试刺激。我们使用四种CS强度系统地研究了从活动到静息M1的SIHI和LIHI。单侧肌肉收缩时的IHI量在SIHI和LIHI之间有显著性差异，而在静息状态下的IHI量无显著性差异。特别是，SIHI在肌肉收缩，但不是LIHI，显着增加CS强度相比，休息条件。在任何实验条件下均未检测到IHI的偏侧性。本研究提供了新的证据，SIHI和LIHI之间的功能差异，从活动到静息M1存在于单侧肌肉收缩。
The aim of the present study was to investigate whether there is a functional difference in short-latency (SIHI) and long-latency (LIHI) interhemispheric inhibition from the active to the resting primary motor cortex (M1) with paired-pulse transcranial magnetic stimulation during a unilateral muscle contraction. In nine healthy right-handed participants, IHI was tested from the dominant to the nondominant M1 and vice versa under resting conditions or during performance of a sustained unilateral muscle contraction with the right or left first dorsal interosseous muscle at 10% and 30% maximum voluntary contraction. To obtain measurements of SIHI and LIHI, a conditioning stimulus (CS) was applied over the M1 contralateral to the muscle contraction, followed by a test stimulus over the M1 ipsilateral to the muscle contraction at short (10 ms) and long (40 ms) interstimulus intervals. We used four CS intensities to investigate SIHI and LIHI from the active to the resting M1 systematically. The amount of IHI during the unilateral muscle contractions showed a significant difference between SIHI and LIHI, but the amount of IHI during the resting condition did not. In particular, SIHI during the muscle contractions, but not LIHI, significantly increased with increase in CS intensity compared with the resting condition. Laterality of IHI was not detected in any of the experimental conditions. The present study provides novel evidence that a functional difference between SIHI and LIHI from the active to the resting M1 exists during unilateral muscle contractions.