Role of hydrostatic and oncotic pressures in renal sodium reabsorption.
Role of hydrostatic and oncotic pressures in renal sodium reabsorption.
复制标题
静水压和胶体渗透压在肾钠重吸收中的作用。
DOI：
10.1161/01.res.52.5.491
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发表时间：
1983
影响因子：
20.1
通讯作者：
Haramati,A
中科院分区：
文献类型：
--
作者：
Knox,FG;Mertz,JI;BurnettJr,JC;Haramati,A
物理因素，特别是肾间质静水压力，对肾脏排钠有重要影响。在某些情况下，但不是所有情况下，肾小管周围微循环中流体静压和肿胀压力的变化可能会对近端小管的重吸收产生影响。在钠排泄控制方面，Henle环可能是一个特别重要的环节，它对跨上皮静水压变化非常敏感。几乎没有证据支持物理因素对远端小管钠重吸收的影响。集合管可能是另一个对压力敏感的部位；然而，肾脏深部肾单位对钠的重吸收的变化可能是归因于集合管的变化。肾内压力的变化可能是调节钠排泄的一个重要环节，特别是在病理情况下，如高血压的过度钠尿和充血性心力衰竭中的钠滞留。
Physical factors, and renal interstitial hydrostatic pressure in particular, have an important effect on sodium excretion by the kidney. Changes in hydrostatic and oncotic pressures in the peritubular microcirculation may have effects on proximal tubule reabsorption under some, but not all, circumstances. In regard to control of sodium excretion, the loop of Henle may be a particularly important segment which is sensitive to transepithelial hydrostatic pressure changes. There is little evidence to support an effect of physical factors on sodium reabsorption by the distal tubule. The collecting tubule may be another pressure-sensitive site; however, changes in sodium reabsorption by deep nephrons in the kidney may account for changes that have been attributed to the collecting duct. Changes in intrarenal pressure may be an important link in the regulation of sodium excretion, particularly in pathological circumstances, such as the exaggerated natriuresis of hypertension and the sodium retention seen in congestive heart failure.