Organization, Transcription, and Regulation in the Animal Genome
Organization, Transcription, and Regulation in the Animal Genome
复制标题
动物基因组的组织、转录和调控
DOI：
--
复制
发表时间：
1973
期刊：
影响因子：
--
通讯作者：
R. Britten
中科院分区：
文献类型：
--
作者：
E. Davidson;R. Britten
本综述涉及动物细胞分子生物学领域与基因调控机制相关的最新实验信息。考虑了有关 DNA 中重复序列元件的散布和聚类的新数据。讨论了动物结构基因和 mRNA 的分子特征，特别是结构基因序列的频率、mRNA 更新和双翅目互补组的解释。综述了核 RNA（主要转录产物）的分子特征。总结了转录水平调节的证据并检查了核和 mRNA 的关系。根据现有知识，进一步开发和考虑了布里顿-戴维森基因调控模型的蛋白质激活剂分支。
This review concerns recent experimental information in areas of animal cell molecular biology which are relevant to the mechanism of gene regulation. New data regarding interspersion and clustering of repetitive sequence elements in DNA are considered. Molecular characteristics of animal structural genes and mRNAs are discussed, with particular reference to the frequency of structural gene sequences, mRNA turnover, and the interpretation of dipteran complementation groups. The molecular characteristics of nuclear RNAs, the primary transcription products, are reviewed. Evidence for transcription level regulation is summarized and the relation of nuclear and mRNA examined. The protein activator branch of the Britten-Davidson model for gene regulations is further developed and considered in ligh of current knowledge.