Loss of neuronal network resilience precedes seizures and determines the ictogenic nature of interictal synaptic perturbations
Loss of neuronal network resilience precedes seizures and determines the ictogenic nature of interictal synaptic perturbations
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DOI：
10.1038/s41593-018-0278-y
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发表时间：
2018-12-01
影响因子：
25
通讯作者：
Jiruska, Premysl
中科院分区：
文献类型：
--
作者：
Chang, Wei-Chih;Kudlacek, Jan;Jiruska, Premysl
癫痫发作的发生机制和发作间期癫痫样放电（IEDs）在癫痫发作中的作用是现代癫痫研究中尚未解决的两个重要问题。我们发现，癫痫发作的转变不是一个突然的现象，而是一个缓慢的过程，其特征是神经网络弹性的逐渐丧失。从动力学的角度来看，缓慢的转变是由临界慢化的原则所支配的，临界慢化是一种鲁棒的自然现象，在以动力学机制之间的转变为特征的系统中是可观察到的。在癫痫中，这一过程受到来自IED的同步突触输入的调制。简易爆炸装置是一种外部扰动，在缓慢的过渡过程中产生阶段性变化，并对癫痫发生网络的动态产生相反的影响，造成抗癫痫发作或促癫痫发作效应。我们发现，IED的多面性是由放电发生时网络的动态状态定义的。
The mechanism of seizure emergence and the role of brief interictal epileptiform discharges (IEDs) in seizure generation are two of the most important unresolved issues in modern epilepsy research. We found that the transition to seizure is not a sudden phenomenon, but is instead a slow process that is characterized by the progressive loss of neuronal network resilience. From a dynamical perspective, the slow transition is governed by the principles of critical slowing, a robust natural phenomenon that is observable in systems characterized by transitions between dynamical regimes. In epilepsy, this process is modulated by synchronous synaptic input from IEDs. IEDs are external perturbations that produce phasic changes in the slow transition process and exert opposing effects on the dynamics of a seizure-generating network, causing either anti-seizure or pro-seizure effects. We found that the multifaceted nature of IEDs is defined by the dynamical state of the network at the moment of the discharge occurrence.