In vivo, high-frequency three-dimensional cardiac MR elastography: Feasibility in normal volunteers.
In vivo, high-frequency three-dimensional cardiac MR elastography: Feasibility in normal volunteers.
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DOI：
10.1002/mrm.26101
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发表时间：
2017-01
影响因子：
3.3
通讯作者：
Araoz PA
中科院分区：
文献类型：
--
作者：
Arani A;Glaser KL;Arunachalam SP;Rossman PJ;Lake DS;Trzasko JD;Manduca A;McGee KP;Ehman RL;Araoz PA
无创硬度成像技术（弹性成像）可以对体内心肌组织生物力学进行成像。对于心脏磁共振弹性成像 (MRE) 技术，体内实验的最佳振动频率未知。此外，心脏 MRE 的准确性从未在几何精确的体模中进行过评估。因此，本研究的目的是确定必要的驱动频率，以便在几何精确的舒张期心脏模型中获得准确的三维 (3D) 心脏 MRE 刚度估计，并确定可在健康志愿者中引入的最佳振动频率。使用 80 Hz、100 Hz、140 Hz、180 Hz 和 220 Hz 振动频率对八名健康志愿者进行 3D 心脏 MRE。这些频率在几何精确的舒张心脏模型中进行了测试，并与动态机械分析 (DMA) 进行了比较。事实证明，3D 心脏 MRE 在高达 180 Hz 的频率下对志愿者是可行的。在心脏模型中频率大于 180 Hz 时，MRE 和 DMA 的一致性在 5% 以内。然而，所有受试者的八面体剪切应变信噪比和心肌覆盖范围在 140 Hz 频率下最高。这项研究激发了未来对患者群体进行高频 3D MRE 的评估。
Noninvasive stiffness imaging techniques (elastography) can image myocardial tissue biomechanics in vivo. For cardiac MR elastography (MRE) techniques, the optimal vibration frequency for in vivo experiments is unknown. Furthermore, the accuracy of cardiac MRE has never been evaluated in a geometrically accurate phantom. Therefore, the purpose of this study was to determine the necessary driving frequency to obtain accurate three-dimensional (3D) cardiac MRE stiffness estimates in a geometrically accurate diastolic cardiac phantom and to determine the optimal vibration frequency that can be introduced in healthy volunteers. The 3D cardiac MRE was performed on eight healthy volunteers using 80 Hz, 100 Hz, 140 Hz, 180 Hz, and 220 Hz vibration frequencies. These frequencies were tested in a geometrically accurate diastolic heart phantom and compared with dynamic mechanical analysis (DMA). The 3D Cardiac MRE was shown to be feasible in volunteers at frequencies as high as 180 Hz. MRE and DMA agreed within 5% at frequencies greater than 180 Hz in the cardiac phantom. However, octahedral shear strain signal to noise ratios and myocardial coverage was shown to be highest at a frequency of 140 Hz across all subjects. This study motivates future evaluation of high-frequency 3D MRE in patient populations.