Tensidols, new potentiators of antifungal miconazole activity, produced by Aspergillus niger FKI-2342
Tensidols, new potentiators of antifungal miconazole activity, produced by Aspergillus niger FKI-2342
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DOI：
10.1038/ja.2006.67
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发表时间：
2006-08-01
影响因子：
3.3
通讯作者：
Omura, Satoshi
中科院分区：
文献类型：
--
作者：
Fukuda, Takashi;Hasegawa, Yoko;Omura, Satoshi
从尼日尔FKI-2342发酵液中分离得到两个新的呋喃并吡咯类化合物，分别命名为tenopyrrolidol A和B。它们的结构均为6-苄基-6H-呋喃并[2，3-B]吡咯。Tenorethols A和B增强咪康唑对白色念珠菌的活性。Tenerols也显示出中等的抗菌活性，仅对梨孢霉。
Two new furopyrrols, designated tensidols A and B, were isolated from the culture broth of Aspergillus niger FKI-2342 by solvent extraction, silica gel column chromatography and HPLC. Their structures were elucidated and shown to have the common skeleton of 6-benzyl-6H-furo[2,3-b]pyrrole. Tensidols A and B potentiated miconazole activity against Candida albicans. Tensidols also showed moderate antimicrobial activity only against Pyricularia oryzae.