Mother/offspring co-administration of the traditional herbal remedy yokukansan during the nursing period influences grooming and cerebellar serotonin levels in a rat model of neurodevelopmental disorders.
Mother/offspring co-administration of the traditional herbal remedy yokukansan during the nursing period influences grooming and cerebellar serotonin levels in a rat model of neurodevelopmental disorders.
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母亲/后代在哺乳期间共同服用传统草药“抑肝散”会影响神经发育障碍大鼠模型的梳理行为和小脑血清素水平。
DOI：
10.1007/s12311-014-0611-2
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Shioda S.
中科院分区：
文献类型：
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作者：
Muneoka K;Kuwagata M;Ogawa T;Shioda S.
多巴胺能系统的神经发育障碍可能与自闭症谱系障碍有关。Yokukansan是一种传统的草药，用于治疗儿童的躁动和躁动，母婴共同给药（云母）是推荐的治疗方法之一。最近的研究揭示了Yokukansan（YKS）的神经药理学特性，包括其5-HT 1A（5-羟色胺）受体激动作用。我们研究了YKS治疗对神经发育障碍动物模型（产前BrdU（5-溴-2 ′-脱氧尿苷）治疗的大鼠（BrdU-大鼠）在新环境中的行为和在哺乳期脑单胺代谢的影响。YKS治疗没有影响BrdU大鼠的自发活动，但减少了在旷场试验中的梳理。没有云母的YKS治疗破坏了运动行为和饲养之间的相关性，并改变了小脑中5-羟色胺及其代谢物的水平。在接受YKS与云母治疗的组中未观察到这些效应。这些数据表明，YKS对梳理行为的发展有直接的药理作用，对小脑5-羟色胺代谢有深远的影响，这被认为是受护理条件的影响。
Neurodevelopmental impairment in the serotonergic system may be involved in autism spectrum disorder. Yokukansan is a traditional herbal remedy for restlessness and agitation in children, and mother–infant co-administration (MICA) to both the child and the nursing mother is one of the recommended treatment approaches. Recent studies have revealed the neuropharmacological properties of Yokukansan (YKS), including its 5-HT1A(serotonin) receptor agonistic effects. We investigated the influence of YKS treatment on behavior in a novel environment and on brain monoamine metabolism during the nursing period in an animal model of neurodevelopmental disorders, prenatally BrdU (5-bromo-2′-deoxyuridine)-treated rats (BrdU-rats). YKS treatment did not influence locomotor activity in BrdU-rats but reduced grooming in open-field tests. YKS treatment without MICA disrupted the correlation between locomotor behaviors and rearing and altered levels of serotonin and its metabolite in the cerebellum. These effects were not observed in the group receiving YKS treatment with MICA. These data indicate a direct pharmacological effect of YKS on the development of grooming behavior and profound effects on cerebellar serotonin metabolism, which is thought to be influenced by nursing conditions.