On the in vitro and in vivo degradation performance and biological response of new biodegradable Mg-Y-Zn alloys
On the in vitro and in vivo degradation performance and biological response of new biodegradable Mg-Y-Zn alloys
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DOI：
10.1016/j.actbio.2009.10.008
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发表时间：
2010-05-01
影响因子：
9.7
通讯作者：
Uggowitzer, Peter J.
中科院分区：
文献类型：
--
作者：
Haenzi, Anja C.;Gerber, Isabel;Uggowitzer, Peter J.
总结了开发新型可生物降解Mg-Y-Zn合金的设计策略，并描述了影响其适用于医疗应用的关键因素。Mg-Y-Zn合金显示出预期适用于血管介入应用的微观结构特征和机械特性。本文的重点在于评价合金作为植入材料（支架）的降解性能和生物学反应。通过浸泡试验和电化学阻抗谱分析，在模拟生理介质中的降解特性揭示了缓慢和均匀的降解。使用人脐静脉内皮细胞进行的体外细胞试验表明，基于合金的洗脱液（浸提液），具有良好的细胞相容性。对猪进行的Mg-2 Y-1 Zn（重量%）动物研究显示出良好的体内性能。对各种类型组织中植入物制备物的评价表明，在体内试验期间均质降解且仅形成有限的气体。组织反应的特点表明具有良好的生物相容性。新的Mg-Y-Zn合金显示出优选的微观结构、机械、电化学和生物学性能的有趣组合，这使得它们非常有希望用于可降解植入物应用。(C)2009 Acta Materialia Inc.由爱思唯尔有限公司出版。保留所有权利。
A design strategy deployed in developing new biodegradable Mg-Y-Zn alloys is summarized and the key factors influencing their suitability for medical applications are described. The Mg-Y-Zn alloys reveal microstructural features and mechanical characteristics expected to be appropriate for vascular intervention applications. The focus of this article lies in the evaluation of the degradation performance and biological response of the alloys with respect to their potential as implant materials (stents). The degradation characteristics analyzed by immersion testing and electrochemical impedance spectroscopy in simulated physiological media reveal slow and homogeneous degradation. In vitro cell tests using human umbilical vein endothelial cells indicate good cytocompatibility on the basis of the alloys' eluates (extracts). Animal studies carried out with pigs on Mg-2Y-1Zn (in wt.%) reveal an auspicious in vivo performance. Evaluation of preparations derived from implants in various types of tissues indicates homogeneous degradation and only limited gas formation during in vivo testing. The characteristics of the tissue reactions indicate good biocompatibility. The new Mg-Y-Zn alloys show an interesting combination of preferred microstructural, mechanical, electrochemical and biological properties, which make them very promising for degradable implant applications. (C) 2009 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.