ANGIOTENSIN-II AND ITS 3-7 FRAGMENT IMPROVE RECOGNITION BUT NOT SPATIAL MEMORY IN RATS
ANGIOTENSIN-II AND ITS 3-7 FRAGMENT IMPROVE RECOGNITION BUT NOT SPATIAL MEMORY IN RATS
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DOI：
10.1016/0361-9230(95)00056-k
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发表时间：
1995-01-01
影响因子：
3.8
通讯作者：
WISNIEWSKI, K
中科院分区：
文献类型：
--
作者：
BRASZKO, JJ;KULAKOWSKA, A;WISNIEWSKI, K
测定侧脑室注射血管紧张素II(AII)及其3-7片段[AII(3-7)]和取代的3-7片段[Leu-5，AII(3-7)]对大鼠空间记忆和再认的影响。在复杂的6室迷宫中，AII(3-7)增加，而Leu-5，AII(3-7)略有减少。接受ALII治疗的动物在迷宫中的表现与注射生理盐水的对照组相似。与对照组相比，所有多肽处理组的总错误数没有变化。除Leu-5，AII(3-7)组外，所有多肽处理组的目标识别能力均显著提高。这些结果表明，AII及其3-7片段对空间记忆没有影响，甚至减弱，但对识别能力有促进作用。Leu-5，AII(3-7)的作用相似，但不太明显。
The effects of angiotensin II (AII), its 3-7 fragment [AII(3-7)] and the substituted 3-7 fragment [Leu-5,AII(3-7)] given intracerebroventricularly (ICV) at the dose of 1 nmole each, on spatial memory and recognition were tested. AII(3-7) increased while Leu-5,AII(3-7) slightly decreased session to session foot shock reinforced runtime to the goal in a complex 6 chamber maze. The animals treated with AII performed in the maze similarly to saline injected controls. Overall number of errors was unchanged in all peptide treated groups in comparison with the control group. Object recognition was significantly improved in all the peptide treated groups except for the Leu-5,AII(3-7) group. The results point to the facilitation of recognition and lack of influence on, or even attenuation of, spatial memory by AII and its 3-7 fragment. Leu-5,AII(3-7) caused similar though less pronounced effects.