Speckle illumination SFDI for projector-free optical property mapping.
Speckle illumination SFDI for projector-free optical property mapping.
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DOI：
10.1364/ol.411187
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发表时间：
2021-02-01
期刊：
影响因子：
3.6
通讯作者：
Durr NJ
中科院分区：
文献类型：
--
作者：
Chen MT;Papadakis M;Durr NJ
空间频域成像可以在宽视场上映射组织散射和吸收特性，使其对于诸如伤口评估和手术引导的临床应用是有用的。该技术以前需要投影完全表征的照明图案。在这里，我们表明，随机和未知的散斑照明可用于采样的调制传递函数的组织在已知的空间频率，允许定量映射的光学特性与简单的激光二极管照明。我们计算低和高的空间频率响应参数的局部功率谱密度为每个像素，并使用一个查找表，以准确地估计吸收和散射系数在组织幻影，在体内人手，和离体猪食道。因为散斑图案可以在大景深和视场上利用简单的相干照明生成，所以该方法可以实现新的形状因子和应用（包括内窥镜检查）中的光学性质映射。
Spatial frequency domain imaging can map tissue scattering and absorption properties over a wide field of view, making it useful for clinical applications such as wound assessment and surgical guidance. This technique has previously required the projection of fully characterized illumination patterns. Here, we show that random and unknown speckle illumination can be used to sample the modulation transfer function of tissues at known spatial frequencies, allowing the quantitative mapping of optical properties with simple laser diode illumination. We compute low- and high-spatial frequency response parameters from the local power spectral density for each pixel and use a lookup table to accurately estimate absorption and scattering coefficients in tissue phantoms, in vivo human hand, and ex vivo swine esophagus. Because speckle patterns can be generated over a large depth of field and field of view with simple coherent illumination, this approach may enable optical property mapping in new form-factors and applications, including endoscopy.