Sex difference in glucose-6-phosphate dehydrogenase activity in the submandibular gland of mice.
Sex difference in glucose-6-phosphate dehydrogenase activity in the submandibular gland of mice.
复制标题
小鼠颌下腺葡萄糖-6-磷酸脱氢酶活性的性别差异。
DOI：
10.1016/0304-4165(74)90032-4
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发表时间：
1974
期刊：
影响因子：
--
通讯作者：
M. Kumegawa
中科院分区：
文献类型：
--
作者：
T. Nakamura;M. Fujii;M. Kaiho;M. Kumegawa
葡萄糖-6-磷酸脱氢酶活性在小鼠颌下腺中存在性别差异，而在舌下腺和腮腺中则不存在性别差异。(1)这种酶活性的性别差异存在于25日龄以上的小鼠。成年小鼠的酶活性为雌鼠的近两倍，雄鼠为72.8M单位/毫克蛋白，雌鼠为38.8M单位/毫克蛋白。(2)成年雄性小鼠去势后酶活性显著降低，用睾酮可完全恢复其活性。雌性小鼠经睾酮处理后，该酶的活性增加到与正常雄性小鼠相当的水平。3.雌性性激素不改变成年雄性小鼠的这种活性。4.(4)糖酵解途径的其他3种关键酶的活性没有发现明显的性别差异。5.(5)大鼠和仓鼠在葡萄糖-6-磷酸脱氢酶活性以及颌下腺颗粒管的大小和数量上只有轻微的性别差异。因此，形态上的性别差异，首先由Lacassagne(Lacassagne，A.(1940)C.R.SoC.比奥尔。133,180-181,227-228,539-540)，反映在酶活性的性别差异上。
A sexual difference in glucose-6-phosphate dehydrogenase activity was found in the submandibular gland of mice but not in the sublingual or parotid gland.1.(1) This sexual difference in enzyme activity was found in mice more than 25 days old. The activity in adult mice was nearly twice as high in males as in females, being 72.8 munits/mg protein in males and 38.8 munits in females.2.(2) Castration of adult male mice markedly decreased the activity, and the activity was completely restored by testosterone administration. Treatment of female mice with testosterone increased the enzyme activity to a level comparable to that in normal males.3.(3) Female sex hormones did not alter the activity in adult male mice.4.(4) No detectable sexual differences were found in the activities of 3 other key enzymes of the glycolytic pathway; hexokinase, phosphofructokinase and pyruvate kinase.5.(5) Rats and hamsters showed only slight sexual differences in glucose-6-phosphate dehydrogenase activity, and in the size and number of granular tubules in their submandibular glands.6.(6) This enzyme activity seemed to be correlated with differentiation of the granular tubules, which is regulated by androgenic steroids. Thus, the sexual differences in morphology, first reported by Lacassagne (Lacassagne, A. (1940) C.R. Soc. Biol. 133, 180–181, 227–228, 539–540), is reflected in a marked sex difference in enzyme activity.