Adjunct Laboratory Tests in the Diagnosis of Early-Onset Neonatal Sepsis
Adjunct Laboratory Tests in the Diagnosis of Early-Onset Neonatal Sepsis
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DOI：
10.1016/j.clp.2009.12.001
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发表时间：
2010-06-01
影响因子：
2.1
通讯作者：
Benitz, William E.
中科院分区：
文献类型：
--
作者：
Benitz, William E.
早发型脓毒症仍然是新生儿医学的主要诊断问题。早期诊断依赖于血液或其他正常无菌体液的培养。异常的血液学计数、急性期反应物和炎性细胞因子既不敏感也不特异，尤其是在发病时。测量的组合提高诊断测试性能，但分析物的最佳选择尚未确定。这些实验室检测的最佳用途是回顾性地确定婴儿没有感染，基于在接下来的24至48小时内没有出现急性期反应。
Early-onset sepsis remains a major diagnostic problem in neonatal medicine. Definitive diagnosis depends on cultures of blood or other normally sterile body fluids. Abnormal hematological counts, acute-phase reactants, and inflammatory cytokines are neither sensitive nor specific, especially at the onset of illness. Combinations of measurements improve diagnostic test performance, but the optimal selection of analytes has not been determined. The best-established use of these laboratory tests is for retrospective determination that an infant was not infected, based on failure to mount an acute-phase response over the following 24 to 48 hours.