Visualizing an olfactory sensory map
Visualizing an olfactory sensory map
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DOI：
10.1016/s0092-8674(00)81387-2
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发表时间：
1996-11-15
期刊：
影响因子：
64.5
通讯作者：
Axel, R
中科院分区：
文献类型：
--
作者：
Mombaerts, P;Wang, F;Axel, R
我们已经开发了一种遗传方法来可视化来自表达给定气味受体的嗅觉感觉神经元的轴突，因为它们投射到嗅球。在小鼠嗅球的1800个肾小球中，表达特定受体的神经元仅投射到两个地形固定的位点。我们的数据提供了直接支持的模型中，一个地形图的受体激活编码嗅球的气味质量。受体交换实验表明，嗅觉受体在指导过程中起着指导作用，但不能在建立这个地图的唯一决定因素。这种遗传学方法可以更广泛地应用于可视化哺乳动物神经系统中投射的发育和可塑性。
We have developed a genetic approach to visualize axons from olfactory sensory neurons expressing a given odorant receptor, as they project to the olfactory bulb. Neurons expressing a specific receptor project to only two topographically fixed loci among the 1800 glomeruli in the mouse olfactory bulb. Our data provide direct support for a model in which a topographic map of receptor activation encodes odor quality in the olfactory bulb. Receptor swap experiments suggest that the olfactory receptor plays an instructive role in the guidance process but cannot be the sole determinant in the establishment of this map. This genetic approach may be more broadly applied to visualize the development and plasticity of projections in the mammalian nervous system.