Catheterized guinea pigs infected with Ebola Zaire virus allows safer sequential sampling to determine the pharmacokinetic profile of a phosphatidylserine-targeting monoclonal antibody
Catheterized guinea pigs infected with Ebola Zaire virus allows safer sequential sampling to determine the pharmacokinetic profile of a phosphatidylserine-targeting monoclonal antibody
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DOI：
10.1016/j.antiviral.2012.11.003
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发表时间：
2013-02-01
影响因子：
7.6
通讯作者：
Hewson, Roger
中科院分区：
文献类型：
--
作者：
Dowall, Stuart;Taylor, Irene;Hewson, Roger
许多药学研究都需要对受到出血热病毒等高致病性生物挑战的动物进行连续采样。使用感染埃博拉病毒的豚鼠模型，使用了导尿管系统，其好处是允许对同一动物队列进行重复采样，并在高度生物遏制下减少锐器的使用。在感染埃博拉病毒的动物和未感染的对照组中，测量了PS靶向抗体(Bavituximab)的水平。数据显示，两组的药代动力学相似，因此埃博拉病毒感染对抗体的半衰期没有明显影响。(C)2012爱思唯尔B.V.保留所有权利。
Sequential sampling from animals challenged with highly pathogenic organisms, such as haemorrhagic fever viruses, is required for many pharmaceutical studies. Using the guinea pig model of Ebola virus infection, a catheterized system was used which had the benefits of allowing repeated sampling of the same cohort of animals, and also a reduction in the use of sharps at high biological containment. Levels of a PS-targeting antibody (Bavituximab) were measured in Ebola-infected animals and uninfected controls. Data showed that the pharmacokinetics were similar in both groups, therefore Ebola virus infection did not have an observable effect on the half-life of the antibody. (C) 2012 Elsevier B.V. All rights reserved.