Ambulatory blood pressure variation is related to plasma renin activity in borderline hypertensive men.
Ambulatory blood pressure variation is related to plasma renin activity in borderline hypertensive men.
复制标题
边缘性高血压男性的动态血压变化与血浆肾素活性有关。
DOI：
10.1093/ajh/4.6.525
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发表时间：
1991
影响因子：
3.2
通讯作者：
Laragh,JH
中科院分区：
文献类型：
--
作者：
James,GD;Pickering,TG;Laragh,JH
本研究的目的是检查未经治疗的高血压白人年龄匹配样本中清醒动态血压变异性与血浆肾素活性（PRA）水平之间的关系。对 376 名男性（145 名 45 岁以下，231 名 45 岁以上）的动态压力进行了三个 PRA 水平的比较：低于 1.0 ng/mL/h、1.0 至 4.0 ng/mL/h 和 4.0 ng/mL/h 或更高。结果显示，平均舒张压随 PRA 下降，尤其是 45 岁以下的男性（95 至 89；P< .05），但在 45 岁及以上的男性中，清醒舒张压变异性与 PRA 水平之间存在很强的正相关关系（p < .001）。这些结果可能具有重要的临床意义，因为较高的 PRA 和较大的血压变异性都与较高的心血管疾病风险相关。美国高血压杂志 1991；4:525 - 528
The purpose of this study was to examine the relationship between the variability of awake ambulatory blood pressure and the level of plasma renin activity (PRA) in age-matched samples of untreated hypertensive white men. The ambulatory pressures of 376 men (145 under 45 years of age, 231 over 45) were compared across three levels of PRA: less than 1.0 ng/mL/h, 1.0 to 4.0 ng/mL/h and 4.0 ng/mL/h or greater. The results showed that the average diastolic pressure declined with PRA, particularly in men under 45 (95 to 89;P< .05), but that among the men 45 and older there was a strong, positive relationship between awake diastolic pressure variability and the level of PRA (p < .001). These results may have important clinical implications since both higher PRA and greater blood pressure variability have been associated with a greater cardiovascular disease risk. Am J Hypertens 1991;4:525 - 528