Biomarker-Measured Unhealthy Alcohol Use in Relation to CD4 Count Among Individuals Starting ART in Sub-Saharan Africa
Biomarker-Measured Unhealthy Alcohol Use in Relation to CD4 Count Among Individuals Starting ART in Sub-Saharan Africa
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DOI：
10.1007/s10461-018-2364-2
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发表时间：
2019-06-01
影响因子：
4.4
通讯作者：
Kiviiri, Ibrahim
中科院分区：
文献类型：
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作者：
Magidson, Jessica F.;Fatch, Robin;Kiviiri, Ibrahim
个人在艾滋病毒疾病的早期阶段开始抗逆转录病毒治疗。不健康的饮酒是成功治疗艾滋病毒的一个已知障碍，但目前还不清楚这个问题是否因疾病阶段而异。我们用一种客观的生物标志物（磷脂酰乙醇[PEth]）测量了酒精使用情况，比较了早期（CD 4>350个细胞/mL，WHO第1阶段）与晚期（CD 4
Individuals are initiating antiretroviral therapy (ART) at earlier HIV disease stages. Unhealthy alcohol use is a known barrier to successful HIV treatment outcomes, yet it is unclear whether the problem varies by disease stage. We measured alcohol use with an objective biomarker (phosphatidylethanol [PEth]), comparing individuals (n=401) with early (CD4>350 cells/mL, WHO Stage 1) versus late (CD4