Nutritional approaches to modulate oxidative stress in Alzheimer's disease.
Nutritional approaches to modulate oxidative stress in Alzheimer's disease.
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DOI：
10.2174/156720511796391908
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发表时间：
2011-07
影响因子：
2.1
通讯作者：
C. Pocernich;M. Lange;R. Sultana;D. Butterfield
中科院分区：
文献类型：
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作者：
C. Pocernich;M. Lange;R. Sultana;D. Butterfield
阿尔茨海默病（AD）脑的特征在于淀粉样β-肽（Aβ）沉积、神经元缠结、突触丢失和广泛的氧化应激。Aβ诱导的氧化应激通过蛋白质氧化、脂质过氧化、自由基形成、DNA氧化和神经元细胞死亡来指示。氧化应激是由抗氧化剂对抗。长期以来，抗氧化剂和营养一直被认为是减缓AD进展的方法。本文综述了抗氧化剂，特别是维生素E、阿魏酸、各种多酚类物质（包括槲皮素和白藜芦醇）、α-硫辛酸、N-乙酰-L-半胱氨酸（NAC）、姜黄素、表没食子儿茶素没食子酸酯（EGCG）和γ-谷氨酰半胱氨酸乙酯（GCEE）。大脑可获得的抗氧化剂具有自由基清除特性和诱导保护基因的能力，被假设为有助于治疗AD。
Alzheimer's disease (AD) brain is characterized by amyloid β-peptide (Aβ) deposits, neurofibrillary tangles, synapse loss, and extensive oxidative stress. Aβ-induced oxidative stress is indexed by protein oxidation, lipid peroxidation, free radical formation, DNA oxidation and neuronal cell death. Oxidative stress is combated by antioxidants. Antioxidants and nutrition have long been considered as an approach to slow down AD progression. In this review, we focus on antioxidants that have been shown to protect against Aβ-induced oxidative stress, particularly vitamin E, ferulic acid, various polyphenols, including quercetin and resveratrol, α-lipoic acid, N-acetyl-L-cysteine (NAC), curcumin, epigallocatechin gallate (EGCG), and γ-glutamylcysteine ethyl ester (GCEE). Brain-accessible antioxidants with both radical scavenging properties and ability to induce protective genes are hypothesized to be helpful in treatment for AD.