Visual performance using a retinal prosthesis in three subjects with retinitis pigmentosa
Visual performance using a retinal prosthesis in three subjects with retinitis pigmentosa
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DOI：
10.1016/j.ajo.2007.01.027
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发表时间：
2007-05-01
影响因子：
4.2
通讯作者：
Humayun, Mark S.
中科院分区：
文献类型：
--
作者：
Yanai, Douglas;Weiland, James D.;Humayun, Mark S.
目得：评估视觉任务的表现在三个盲人科目植入epiretinal prosthes.DESIGN：前瞻性，研究设备exemption trial.METHODS：三个科目与光感知或没有光感知视力在一个单一的中心。所有受试者均患有视网膜色素变性（RP）。主要入选标准：单眼光感或视力变差，失明前成年时有一定的视觉经验。主要排除标准包括其他眼科问题。将原型视网膜假体植入光敏感性较差的眼睛中。该假体具有固定到视网膜前表面的4 × 4铂电极阵列。假肢由计算机或头戴式摄像机无线控制。以单盲或双盲方式进行视觉功能测试。从视觉任务的分数进行了比较，以确定统计significance.RESULTS：在83%的测试中，受试者的表现显着优于机会。使用摄像机，受试者在简单的视觉任务中得分如下：定位和计数物体（77%至100%），区分三个物体（63%至73%），确定大写字母L的方向（50%至77%），以及区分移动物体的四个方向（40%至90%）。测试的一个子集比较了使用多像素与单像素的相机设置。使用多像素设置，受试者表现更好（17%）或同等（83%）的准确性和更好（25%）或同等（75%）的反应时间。结论：三RP植入受试者使用视网膜前假体执行简单的视觉任务。多个。像素设置证明比单像素设置稍微更有效。
PURPOSE: To assess visual task performance in three blind subjects implanted with epiretinal prostheses.DESIGN: Prospective, investigational device exemption trial.METHODS: Three subjects with light perception or no light perception vision were enrolled at a single center. All subjects had retinitis pigmentosa (RP). Main inclusion criteria: light perception or worse vision in one eye and some visual experience as an adult before blindness. Main exclusion criteria included other ophthalmic problems. A prototype retinal prosthesis was implanted in the eye with worse light sensitivity. The prosthesis had 4 x 4 array of platinum electrodes tacked to the epiretinal surface. The prosthesis was wirelessly controlled by a computer or by a head,worn video camera. Visual function testing was performed in single masked or double masked fashion. Scores from the visual task were compared to chance to determine statistical significance.RESULTS: The subjects performed significantly better than chance in 83% of the tests. Using the video camera, subjects scored as follows on simple visual tasks: locate and count objects (77% to 100%), differentiate three objects (63% to 73%), determine the orientation of a capital L (50% to 77%), and differentiate four directions of a moving object (40% to 90%). A subset of tests compared camera settings using multipixels vs single pixels. Using multipixel settings, subjects performed better (17%) or equivalent (83%) in accuracy and better (25%) or equivalent (75%) in reaction time.CONCLUSIONS: Three RP implant subjects used epiretinal prostheses to perform simple visual tasks. Multi. pixel settings proved slightly more effective than single pixel settings.