Increased interleukin-6 and high-sensitivity C-reactive protein levels in pediatric epilepsy patients with frequent, refractory generalized motor seizures
Increased interleukin-6 and high-sensitivity C-reactive protein levels in pediatric epilepsy patients with frequent, refractory generalized motor seizures
复制标题
DOI：
10.1016/j.seizure.2014.10.007
复制
发表时间：
2015-02-01
影响因子：
3
通讯作者：
Kobayashi, Masao
中科院分区：
文献类型：
--
作者：
Ishikawa, Nobustune;Kobayashi, Yoshiyuki;Kobayashi, Masao
目的：最近发现慢性炎症参与多种器官慢性疾病的病理机制。越来越多的证据表明炎症过程影响癫痫的病理生理学。我们研究了炎症标志物，以确定儿童顽固性癫痫病理生理学背后的慢性炎症过程。方法：总共纳入了 29 名癫痫患者和 15 名儿童作为对照受试者。患者被分为 DS（每日全身性运动性癫痫发作）组和 IS（间歇性癫痫发作）组。对所有参与者的血清高敏 C 反应蛋白 (hs-CRP)、血浆五聚蛋白 3 (PTX3)、血清肿瘤坏死因子 (TNF)-α、白细胞介素 (IL)-6 和 IL-β 1 的血液水平进行了评估。结果：DS 组的 Hs-CRP 水平 (0.149 +/- 0.161 mg/dL) 显着高于 IS 组或对照组 (0.0156) +/- 0.0136 和 0.0253 +/- 0.0288 mg/dL，分别为 p < 0.005 和 p < 0.05），而 IS 组和对照组之间没有显着差异。 DS 组的 IL-6 水平 (8.022 +/- 0.161 pg/mL) 也显着高于 IS 组或对照组 (7.783 +/- 0.0563 和 7.864 +/- 0.072 pg/mL；分别为 p < 0.005 和 p < 0.05)。 PTX3、TNF-α 或 IL-1 β 水平没有显着差异。结论：我们的结果表明，日常全身运动性癫痫发作会导致 IL-6 水平升高，从而导致 CRP 升高。频繁全身运动性癫痫发作的难治性患者的全身炎症反应可能会影响其预后。我们可能需要治疗策略，包括控制炎症过程的方法，来治疗顽固性癫痫。 (C) 2014 年英国癫痫协会。由爱思唯尔有限公司出版。保留所有权利。
Purpose: Recently, it was found that chronic inflammation contributes to the pathomechanism of diverse chronic diseases in various organs. There is accumulating evidence that inflammatory processes affect the pathophysiology of epilepsy. We investigated inflammatory markers to determine the chronic inflammatory process underlying the pathophysiology of intractable epilepsy presenting with frequent motor seizures in children.Method: In total, 29 patients with epilepsy and 15 children as control subjects were enrolled. Patients were divided into the DS (daily generalized motor seizures) and the IS (intermittent seizures) groups. Blood levels of serum high-sensitivity C-reactive protein (hs-CRP), plasma pentraxin 3 (PTX3), serum tumor necrosis factor (TNF)-alpha, interleukin (IL)-6, and IL-beta 1 were evaluated in all participants.Results: Hs-CRP levels were significantly higher in the DS group (0.149 +/- 0.161 mg/dL) than in either the IS or control group (0.0156 +/- 0.0136 and 0.0253 +/- 0.0288 mg/dL, p < 0.005 and p < 0.05, respectively), while there was no significant difference between the IS and control groups. The IL-6 level was also significantly higher in the DS group (8.022 +/- 0.161 pg/mL) than in either the IS or the control group (7.783 +/- 0.0563 and 7.864 +/- 0.072 pg/mL; p < 0.005 and p < 0.05, respectively). There were no significant differences in PTX3, TNF-alpha, or IL-1 beta levels.Conclusion: Our results suggest that daily generalized motor seizures result in elevated IL-6 levels, leading to increased CRP. A systemic inflammatory response in intractable patients with frequent generalized motor seizures may affect their prognosis. We may need therapeutic strategies, including methods to control the inflammatory process, to treat intractable epilepsy. (C) 2014 British Epilepsy Association. Published by Elsevier Ltd. All rights reserved.