Comparison of Acute Withdrawal and Slow Taper of Antiseizure Medications during Video Electroencephalographic Monitoring: Efficacy for Shortening of Hospital Stay.
Comparison of Acute Withdrawal and Slow Taper of Antiseizure Medications during Video Electroencephalographic Monitoring: Efficacy for Shortening of Hospital Stay.
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DOI：
10.3390/jcm10245972
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发表时间：
2021-12-20
影响因子：
3.9
通讯作者：
Murai H
中科院分区：
文献类型：
--
作者：
Motoki A;Akamatsu N;Fumuro T;Miyoshi A;Tanaka H;Hagiwara K;Ohara S;Kamada T;Shigeto H;Murai H
抗癫痫药物（ASM）在癫痫监测单元被撤回，以促进癫痫发作记录。ASMs的快速减量对住院时间的影响尚未得到很好的记录。我们比较了在长期视频脑电图（EEG）监测期间接受急性ASM戒断和缓慢剂量递减的患者的平均住院时间。我们回顾性调查了57例癫痫监测中心收治的急性ASM戒断组（n = 30）和缓慢减量组（n = 27）的平均住院时间。在急性戒断组中，一旦患者入院，所有ASM均被停用。在缓慢减量组中，ASM的剂量每天逐渐减少15-30%。我们还评估了急性撤药和缓慢减量方案的安全性。急性戒断组和缓慢减量组的平均住院时间分别为3.8 ± 1.92和5.2 ± 0.69天（p < 0.005）。未观察到严重不良事件，包括癫痫持续状态。与缓慢减量相比，急性ASM戒断具有显著缩短住院时间的优势，且无任何严重不良反应。
Antiepileptic medications (ASMs) are withdrawn at the epilepsy monitoring unit to facilitate seizure recordings. The effect of rapid tapering of ASMs on the length of hospital stay has not been well documented. We compared the mean length of hospital stay between patients who underwent acute ASM withdrawal and slow dose tapering during long-term video electroencephalography (EEG) monitoring. We retrospectively investigated 57 consecutive patients admitted to the epilepsy monitoring unit regarding the mean length of hospital stay in the acute ASM withdrawal group (n = 30) and slow-taper group (n = 27). In the acute-withdrawal group, all ASMs were discontinued once the patients were admitted. In the slow-taper group, the doses of ASMs were gradually reduced by 15–30% daily. We also evaluated the safety of the acute-withdrawal and slow-taper protocols. The mean lengths of hospital stay were 3.8 ± 1.92 and 5.2 ± 0.69 days in the acute-withdrawal and slow-taper groups, respectively (p < 0.005). No severe adverse events, including status epilepticus, were observed. Acute ASM withdrawal has the advantage of significantly reducing the length of hospital stay over slow tapering, without any severe adverse effects.
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影响因子：
5.6
作者：
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通讯作者：
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