Mononuclear cell tissue factor: cell of origin and requirements for activation
Mononuclear cell tissue factor: cell of origin and requirements for activation
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单核细胞组织因子：细胞起源和激活要求
DOI：
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发表时间：
1979
期刊：
影响因子：
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通讯作者：
A. Bobrove
中科院分区：
文献类型：
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作者：
R. Edwards;F. Rickles;A. Bobrove
人单核白细胞在体外受内毒素、丝裂原或抗原刺激后产生促凝物质组织因子（TF）。为了确定单核细胞TF的细胞来源和体外最大TF生成所需的条件，我们研究了用各种方法制备的单核细胞亚群的组织因子生成。我们还研究了体外TF生成与体内或体外对相同抗原刺激反应的延迟超敏反应之间的关系。我们的结果表明，单核细胞在体外产生了大部分的单核细胞TF，单独的粘附不足以刺激显著。
Human mononuclear leukocytes generate the procoagulant material tissue factor (TF) following stimulation by endotoxin, mitogens, or antigens in vitro. We have examined tissue-factor generation by mononuclear cell subpopulations prepared in a variety of ways in order to determine the cell of origin of mononuclear cell TF and the conditions necessary for maximal in vitro TF generation. We have also examined the relationship between in vitro TF generation and in vivo or in vitro measures of delayed hypersensitivity in response to identical antigen stimulation. Our results demonstrate that the monocyte is responsible for the bulk of mononuclear cell TF generation in vitro and that adhesion alone is not sufficient stimulation for significant.