Clinical Significance of Simultaneous Determination of Serum Tryptophan and Tyrosine in Patients With Lung Cancer
Clinical Significance of Simultaneous Determination of Serum Tryptophan and Tyrosine in Patients With Lung Cancer
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DOI：
10.1002/jcla.20467
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发表时间：
2011-01-01
影响因子：
2.7
通讯作者：
Xiang, Zhong-Yuan
中科院分区：
文献类型：
--
作者：
Ren, Ya-Ping;Tang, Ai-Guo;Xiang, Zhong-Yuan
背景：为探讨肺癌患者血清酪氨酸（Tyr）和色氨酸（Trp）含量的临床意义，采用简便高效的高效液相色谱-荧光检测（HPLC-FD）同时测定血清色氨酸（Trp）和酪氨酸（Tyr）含量。方法：采用高效液相色谱法同时测定80例肺癌患者和120例健康对照者血清中酪氨酸和色氨酸的浓度。结果：肺癌患者血清色氨酸浓度明显低于健康对照组（分别为39.26 +/- 5.44和49.93 +/- 5.43 mmol/l, P0.05）。此外，腺癌组患者的Trp和Tyr浓度明显低于鳞状细胞癌组。早期和晚期肺癌无明显差异。结论：血清色氨酸（Trp）和酪氨酸（Tyr）浓度的测定可辅助肺癌组织分型和分期的诊断。Tyr和Trp作为肺癌诊断敏感性指标，特异性分别为54.9、62.9%和82.4、92.1%，Trp是肺癌诊断的重要而特殊的指标，其诊断肺癌的特异性大于92%。j .中国。实验室。植物学报。25:246-250,2011。(C) 2011 Wiley-Liss, Inc。
Background: To explore the clinical significance of serum tyrosine (Tyr) and tryptophan (Trp) in patients with lung cancer, we used a simple and efficient method of high-performance liquid chromatography with fluorescence detection (HPLC-FD) that simultaneously measured serum Trp and Tyr contents. Methods: The concentrations of Tyr and Trp were measured simultaneously by HPLC-FD in the sera of 80 patients with lung cancer and 120 healthy controls. Results: Trp concentrations were significantly lower in patients with lung cancer than in healthy controls (39.26 +/- 5.44 vs. 49.93 +/- 5.43 mmol/l, respectively; P0.05). In addition, patients in the adenocarcinoma group had significantly lower Trp and Tyr concentrations than those in squamous cell carcinoma group. There was no difference between the early stage and advanced stage of lung cancer. Conclusions: Determination of serum Trp and Tyr concentrations can be employed to assist the diagnosis of the histotypes of lung cancer and tumor stage. Tyr and Trp as indexes on the lung cancer diagnostic sensitivity, specificity were 54.9, 62.9% and 82.4, 92.1%, Trp is an important and special index for lung cancer diagnosis of which the specificity of diagnosis of lung cancer is more than 92%. J. Clin. Lab. Anal. 25: 246-250, 2011. (C) 2011 Wiley-Liss, Inc.