Effects of temperature and other factors on the toxicity of methylmercury in mice.
Effects of temperature and other factors on the toxicity of methylmercury in mice.
复制标题
温度等因素对甲基汞对小鼠毒性的影响。
DOI：
10.1016/0041-008x(80)90073-3
复制
发表时间：
1980
影响因子：
3.8
通讯作者：
H. Nomiyama
中科院分区：
文献类型：
--
作者：
K. Nomiyama;K. Matsui;H. Nomiyama
Male and female mice of the RF and ICR strains at various ages were given methylmercury chloride orally at a dose level of 30 mg Hg/kg, and the accumulated rates of death were compared. Higher accumulation rates of death were observed as follows: greater in RF strain mice than in ICR strain mice, in male mice than in female mice, and in aged mice than in young mice. The mechanisms of age and sex difference in methylmercury toxicity were not clarified by the determination of total mercury and methylmercury in the brains. The accumulated rates of death after a single oral methylmercury administration at a dose level of 30 mg Hg/kg were also compared among three groups of mice, which were previously acclimatized to an environmental temperature of 8, 22, or 38°C. The highest toxicity was found when the environmental temperature was 8°C, followed by those at 22 and 38°C. The mechanism of the aggravating effects of low environmental temperature in methylmercury toxicity was studied in relation to the critical concentration. The toxicity of methylmercury was attenuated by keeping animals warm by putting them on a warming mat or placing them in a room with higher environmental temperature.
