Access to Z-Selective 1,3-Enynes via Ni-Catalyzed Intermolecular Cross-Alkylalkynylation of Terminal Alkynes.
Access to Z-Selective 1,3-Enynes via Ni-Catalyzed Intermolecular Cross-Alkylalkynylation of Terminal Alkynes.
复制标题
通过镍催化末端炔烃的分子间交叉烷基炔基化获得 Z-选择性 1,3-烯炔。
DOI：
10.1021/acs.orglett.1c01728
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发表时间：
2021-06
期刊：
影响因子：
5.2
通讯作者：
Shu Wei
中科院分区：
文献类型：
--
作者：
Xiao Nan;Zhan Yi-Zhou;Meng Huan;Shu Wei
Access to 1,3-conjugated enynes with defined stereoselectivity is highly desirable and challenging. Herein, we report a facile synthesis of stereodefined 1,3-conjugated enynes via Ni-catalyzed intermolecular cross-alkylalkynylation of alkynes with unsaturated carbonyl compounds and alkynes or alkynyl silicates. The operational simple protocol proceeds at room temperature and tolerates a wide range of functional groups, providing an attractive alternative to carbonyl-tethered trisubstituted conjugated 1,3-enynes from easily accessible starting materials.
